Cardiovascular diseases are the leading cause of mortality in the world [1]. The carotid-artery intima-media thickness (IMT) is strongly correlated with cardiovascular diseases [2], but tends to overestimate the risk. Recently a promising predictor has been discovered: the IMT temporal variation during the cardiac cycle, which reflects the arterial stiffness and may be more sensitive than classical risk markers [3]. Few teams have worked on its estimation [3,4,5,6]; existing methods separately delineate the arterial wall in a series of B-Mode images to deduce a single IMT value at each time point. Their evaluation against contours manually traced in B-mode images is tedious and does not exploit the temporal consistency. In this paper, we investigate a less time-consuming process devised to create a temporally consistent manual reference.1. World Health Organization (WHO). Fact Sheet No. 317 at : http://www.who.int/mediacentre/factsheets/fs317/en/2. Bots, ML. et al. Circulation 96(5):1432-1437, 1997.3. Zahnd G. et al. Int J CARS, 9:645-658, 2014.4. Ilea DE et al. IEEE UFFC, 60(1):158-177, 2013.5. Cinthio M. et al. Proc IEEE US Symp 389-391, 2005.6. Zahnd G. et al. Ultrasound Med Biol, 43:1,239-257, 2017.