Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance

Abstract :

Monoclonal gammopathies of undetermined significance (MGUS) have been shown to be associated with an increased risk of fractures. This study describes prospectively the bone status of MGUS patients and determines the factors associated with vertebral fracture. We included prospectively 201 patients with MGUS, incidentally discovered, and with no known history of osteoporosis: mean age 66.6±12.5 years, 48.3% women, 51.7% immunoglobulin G (IgG), 33.3% IgM and 10.4% IgA. Light chain was kappa in 64.2% patients. All patients had spinal radiographs and bone mineral density measurement in addition to gammopathy assessment. At least one prevalent non-traumatic vertebral fracture was discovered in 18.4% patients and equally distributed between men and women. Fractured patients were older, had a lower bone density and had also more frequently a lambda light chain isotype. Compared with patients with κ light chain, the odds ratio of being fractured for patients with λ light chain was 4.32 (95% confidence interval 1.80-11.16; P=0.002). These results suggest a high prevalence of non-traumatic vertebral fractures in MGUS associated with lambda light chain isotype and not only explained by low bone density.

Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-01392246
Contributeur : Okina Université d'Angers <>
Soumis le : vendredi 4 novembre 2016 - 11:04:38
Dernière modification le : vendredi 19 juin 2020 - 03:27:29

Lien texte intégral

Identifiants

Collections

Citation

J Piot, Mathieu Royer, Aline Tanguy-Schmidt, Emmanuel Hoppé, Martine Gardembas, et al.. Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance. Blood Cancer Journal, Nature Publishing Group, 2015, 5, pp.e345. ⟨10.1038/bcj.2015.71⟩. ⟨hal-01392246⟩

Partager

Métriques

Consultations de la notice

150