THE TRIS FORMULATION OF FLUOROURACIL IS MORE CARDIOTOXIC THAN THE SODIUM-SALT FORMULATIONS

Abstract : The cardiotoxicity of 5-fluorouracil (FU) was attributed to degradation compounds present in the injected vials, fluoroacetaldehyde (Facet) and fluoromalonaldehydic acid (FMald). FU-NaOH vials were much less cardiotoxic than FU-Tris vials on the isolated perfused rabbit heart model since Facet and FMald are stored in stable depot forms in FU-Tris vials whereas, in FU-NaOH vials, they are extensively transformed. Cardiotoxic fluoroacetate (FAG), coming from Facet metabolization, was found in urine of patients, with a ratio FAC /FU catabolites 10-30 fold lower in patients treated with FU-NaOH than in those treated with FU-Tris.
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https://hal.univ-angers.fr/hal-02374762
Contributeur : Laurent Lemaire <>
Soumis le : jeudi 21 novembre 2019 - 16:23:42
Dernière modification le : vendredi 22 novembre 2019 - 01:36:31

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Laurent Lemaire, Mc Maletmartino, R. Martino, M Deforni, B Lasserre. THE TRIS FORMULATION OF FLUOROURACIL IS MORE CARDIOTOXIC THAN THE SODIUM-SALT FORMULATIONS. Oncology Reports, Spandidos Publications, 1994, 1 (1), pp.173-4. ⟨10.3892/or.1.1.173⟩. ⟨hal-02374762⟩

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