Assessment of induced rat mammary tumour response to chemotherapy using the apparent diffusion coefficient of tissue water as determined by diffusion-weighted1H-NMR spectroscopy in vivo

Abstract : Chemosensitivity of N-methyl-N-nitrosourea-induced rat mammary tumours treated with 5-fluorouracil at a dose of 100 mg kg(-1) i.p. was assessed by using diffusion-weighted 1H-MRS to measure the average diffusion coefficient (ADC) of water in the tumour tissue. ADC measurements prior to any therapy correlated positively with necrotic fraction. Tumours with low initial ADC (< 0.95 x 10(9) m2 s(-1)) showed an increase in ADC 7 days after treatment, whereas tumours with a high initial ADC (> 1.2 x 10(9) m2 s(-1)) showed a decrease. All tumours decreased significantly in volume (P < 0.05) 2, 5 and 7 days after treatment. At day 7 post-treatment, tumours with a high pre-treatment ADC started to regrow. The initial ADC value, as well as changes after treatment predict tumour chemosensitivity, which could be clinically relevant.
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https://hal.univ-angers.fr/hal-02374789
Contributeur : Laurent Lemaire <>
Soumis le : jeudi 21 novembre 2019 - 16:34:45
Dernière modification le : vendredi 22 novembre 2019 - 01:36:12

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Laurent Lemaire, Franklyn Howe, Loreta Rodrigues, John Griffiths. Assessment of induced rat mammary tumour response to chemotherapy using the apparent diffusion coefficient of tissue water as determined by diffusion-weighted1H-NMR spectroscopy in vivo. Magnetic Resonance Materials in Physics, Biology and Medicine, Springer Verlag, 1999, 8 (1), pp.20-26. ⟨10.1007/bf02590631⟩. ⟨hal-02374789⟩

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