Is magnetic resonance imaging texture analysis a useful tool for cell therapy in vivo monitoring?

P Eliat D Lechaux A Gervais N. Rioux-Leclerc 1 F. Franconi 2 Laurent Lemaire 2 L Dazord V Catros-Quemener J de Certaines
1 CHU Pontchaillou [Rennes]
2 MINT - Micro et Nanomédecines Translationnelles
Abstract : Assessment of anti-tumor treatment efficiency is usually done by measuring tumor size. Treatment may however induce changes in the tumor other than tumor size. Magnetic Resonance Imaging Texture Analysis (MRI-TA) is presently used to follow activated lymphocyte cell therapy. We used a 7T microimager to acquire high-resolution MR images of an experimental liver metastasis from colon carcinoma in rats treated (n = 4) or not (n = 3) with a cell therapy product. MRI-TA was then performed with Linear Discriminant Analysis and showed: i) a significant variation of tumor texture with tumor growth and ii) a significant modification in the texture of tumors treated with activated lymphocytes compared with untreated tumors. T2-weighted images or volume calculation did not evidence any difference. MRI-TA appears as a promising method for early detection and follow-up of response to cell therapy.
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https://hal.univ-angers.fr/hal-02375434
Contributeur : Laurent Lemaire <>
Soumis le : vendredi 22 novembre 2019 - 08:29:11
Dernière modification le : samedi 23 novembre 2019 - 01:39:02

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  • HAL Id : hal-02375434, version 1
  • PUBMED : 11911258

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UNIV-ANGERS | INC-CNRS | CNRS

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P Eliat, D Lechaux, A Gervais, N. Rioux-Leclerc, F. Franconi, et al.. Is magnetic resonance imaging texture analysis a useful tool for cell therapy in vivo monitoring?. Anticancer Research, International Institute of Anticancer Research, 1970, 21 (6A), pp.3857-60. ⟨hal-02375434⟩

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