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Article dans une revue
Is magnetic resonance imaging texture analysis a useful tool for cell therapy in vivo monitoring?
Abstract : Assessment of anti-tumor treatment efficiency is usually done by measuring tumor size. Treatment may however induce changes in the tumor other than tumor size. Magnetic Resonance Imaging Texture Analysis (MRI-TA) is presently used to follow activated lymphocyte cell therapy. We used a 7T microimager to acquire high-resolution MR images of an experimental liver metastasis from colon carcinoma in rats treated (n = 4) or not (n = 3) with a cell therapy product. MRI-TA was then performed with Linear Discriminant Analysis and showed: i) a significant variation of tumor texture with tumor growth and ii) a significant modification in the texture of tumors treated with activated lymphocytes compared with untreated tumors. T2-weighted images or volume calculation did not evidence any difference. MRI-TA appears as a promising method for early detection and follow-up of response to cell therapy.
https://hal.univ-angers.fr/hal-02375434
Contributeur : Laurent Lemaire <>
Soumis le : vendredi 22 novembre 2019 - 08:29:11
Dernière modification le : lundi 16 décembre 2019 - 12:05:44
Contributeur : Laurent Lemaire <>
Soumis le : vendredi 22 novembre 2019 - 08:29:11
Dernière modification le : lundi 16 décembre 2019 - 12:05:44
