Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Recreational phenethylamine poisonings reported to a French poison control center

Abstract : Objectives Over the last decade, use of phenethylamines has become increasingly prevalent. This study aimed to describe typical aspects of phenethylamine poisoning in order to better inform patient care. Methods Phenethylamine poisoning cases reported to the Poison Control Center of Angers, France, from January, 2007 to December, 2013 were examined. Clinical findings were examined in 105 patients, including phenethylamine used, symptoms and final outcome. Patients were predominantly male (80%), with mean age 26 ± 8 years. Results MDMA (38%), amphetamine (18%) and methamphetamine (14%) were the most commonly reported. Synthetic cathinones (10%) and the 2C series (7%) were also found. Substances most commonly associated with phenethylamine poisoning were cannabis (27%), ethanol (20%) and cocaine (9%). The most frequently reported symptoms included anxiety and hallucinations (49%), mydriasis and headache (41%), tachycardia (40%) and hypertension (15%). Complications such as seizures (7%), cardiac arrest (5%), toxic myocarditis (1%) and hemorrhagic stroke (1%) were also observed. Of the cases, the Poison Severity Score was: null or low, 66%, moderate, 21%, severe or fatal, 13%. Of the patients, 77% received hospital care and 12.4% were admitted to an intensive care unit. Analytical confirmations were obtained for all severe cases. While 93% of patients recovered, there were 5 deaths and 2 patients presented with neurological sequelae. Conclusions Phenethylamine poisonings may be severe in young and healthy individuals. Physicians, toxicologists and analysts should be aware of new phenethylamine consumption trends in order to inform management of patient care and to contribute to a more responsive drug policy.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [27 références]  Voir  Masquer  Télécharger

https://hal.univ-angers.fr/hal-02395009
Contributeur : Nathalie Clement <>
Soumis le : jeudi 16 avril 2020 - 12:26:13
Dernière modification le : mercredi 17 juin 2020 - 23:24:03

Fichier

j.drugalcdep.2015.05.048.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Gaël Le Roux, Chloé Bruneau, Bénédicte Lelièvre, Marie Bretaudeau Deguigne, Alain Turcant, et al.. Recreational phenethylamine poisonings reported to a French poison control center. Drug and Alcohol Dependence, Elsevier, 2015, 154, pp.46-53. ⟨10.1016/j.drugalcdep.2015.05.048⟩. ⟨hal-02395009⟩

Partager

Métriques

Consultations de la notice

75

Téléchargements de fichiers

66