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Prosthetic Valve Candida spp. Endocarditis: New Insights Into Long-term Prognosis—The ESCAPE Study

Claire Rivoisy 1 Antonio Vena 2, 3, 4 Laura Schaeffer 5 Caroline Charlier 1 Arnaud Fontanet 5, 6 François Delahaye 7, 8 Emilio Bouza 2, 4, 3 Olivier Lortholary 1, 9 Patricia Muñoz 2, 4, 3 Agnès Lefort 10, 11, * Yazdan Yazdanpanah 11 Michel Wolff Sandrine Houze 12 Tristan Ferry Martine Wallon 13 Christophe Strady Dominique Toubas 14 Nicolas Bréchot 15 Benoît Henry 16, 17 Arnaud Fekkar 17 Thierry Fourme Isabelle Amouroux Jean-Luc Mainardi 18 Eric Dannaoui 9 Olivier Rogeaux 19 Marion Levast 20 Catherine Chirouze 21 Laurence Million 21 Frédéric Bastides 22 Jacques Chandenier 23 Jean-Pierre Lançon Anne Ovize 24 Pierre Abgueguen 25 Jean-Philippe Bouchara 26 Laurent Tric Gilbert Habib 27 Frederic Gourriet Laurent Aaron Marie Elisabeth Bougnoux 28 Fabrice Camou 29 Isabelle Accoceberry 30 Fernando Fernández Sánchez Mariam Noureddine Gabriel Rosas Javier de la Torre Lima José Aramendi Elena Bereciartua María Victoria Boado Marta Campaña Lázaro Josune Goikoetxea Juan José Goiti José Luis Hernández José Ramón Iruretagoyena Josu Irurzun Zuazabal Leire López-Soria Miguel Montejo Pedro María Pérez Regino Rodríguez Roberto Voces Mª Victoria García López Radka Ivanova Georgieva Manuel Márquez Solero Isabel Rodríguez Bailón Josefa Ruiz Morales Ana María Cuende Tomás Echeverría Ana Fuerte Eduardo Gaminde Miguel Ángel Goenaga Pedro Idígoras José Antonio Iribarren Alberto Izaguirre Yarza Xabier Kortajarena Urkola Carlos Reviejo Rafael Carrasco 31 Vicente Climent Patricio Llamas Esperanza Merino Joaquín Plazas Sergio Reus Nemesio Álvarez Jose María Bravo-Ferrer Laura Castelo José Cuenca Pedro Llinares Enrique Miguez Rey María Rodríguez Mayo Efrén Sánchez Dolores Sousa Regueiro Francisco Javier Martinez 32 Mª del Mar Alonso Beatriz Castro Dácil García Marrero Mª del Carmen Durán Mª Antonia Miguel Gómez Juan La Calzada Ibrahim Nassar Antonio Plata Ciezar José Mª Reguera Iglesias Víctor Asensio Carlos Costas Jesús de la Hera Jonnathan Fernández Suárez Lisardo Iglesias Fraile Víctor León Arguero José López Menéndez Pilar Menciabajo Carlos Morales 33 Alfonso Moreno Torrico Carmen Palomo Begoña Paya Martínez Ángeles Rodríguez Esteban Raquel Rodríguez García Mauricio Telenti Asensio Manuel Almela Yolanda Armero Manuel Azqueta Merce Brunet 34 Ramón Cartañá Carlos Cervera Carlos Falces Guillermina Fita David Fuster Cristina García de la Maria José Gatell 35 Jaume Llopis Pérez Francesc Marco Carlos Mestres José Mª Miró Asunción Moreno Salvador Ninot Eduardo Quintana Carlos Paré Juan Manuel Pericás José Pomar José Ramírez 36 Irene Rovira Marta Sitges 37 Dolors Soy Adrián Téllez Jordi Vila Javier Bermejo Gregorio Cuerpo Viviana de Egea Alia Eworo Ana Fernández Cruz Mª Eugenia García Leoni Marcela González del Vecchio Víctor González Ramallo Martha Kestler Hernández Mercedes Marín Manuel Martínez-Sellés Mª Cruz Menárguez Cristina Rincón Hugo Rodríguez-Abella Marta Rodríguez-Créixems Blanca Pinilla Ángel Pinto Maricela Valerio Eduardo Verde Moreno Isabel Antorrena Belén Loeches Mar Moreno Ulises Ramírez Verónica Rial Bastón María Romero Araceli Saldaña Carlos Armiñanzas Castillo Ana Arnaiz José Berrazueta Sara Bellisco Manuel Cobo Belaustegui Raquel Durán Mªcarmen Fariñas Concepción Fariñas-Álvarez Carlos Fernández Mazarrasa Rubén Gómez Izquierdo Claudia González Rico José Gutiérrez Díez Rafael Martín Durán Marcos Pajarón José Antonio Parra Ramón Teira Jesús Zarauza Pablo García Pavía Jesús González Beatriz Orden Antonio Ramos 38 Elena Rodríguez González; Tomasa Centella José Manuel Hermida José Luis Moya Pilar Martín-Dávila Enrique Navas Enrique Oliva Alejandro del Río Soledad Ruiz Carmen Hidalgo Tenorio Antonio de Castro Marina de Cueto Pastora Gallego Juan Gálvez Acebal Jesús Rodríguez Baño Arístides de Alarcón Emilio García Juan Luis Haro José Antonio Lepe Francisco López Rafael Luque 39 Luis Javier Alonso José Manuel Azcona Gutiérrez José Ramón Blanco Lara García José Antonio Oteo Natividad de Benito Mercé Gurguí Cristina Pacho Roser Pericas 40 Guillem Pons M. Alvarez 41 A Fernández A. Prieto 42 Benito Regueiro E Tijeira Marino Vega Andrés Canut Blasco José Cordo Mollar Juan Carlos Gainzarain Arana Oscar García Uriarte Alejandro Martín López Zuriñe Ortiz de Zárate José Antonio Urturi Matos Mª Belén Nacle Antonio Sánchez-Porto Luis Vallejo José Mª Arribasleal Elisa García Vázquez Alicia Hernández Torres Ana Blázquez Gonzalo de la Morena Valenzuela Ángel Alonso Javier Aramburu Felicitas Elena Calvo Anai Moreno Rodríguez Paola Tarabini-Castellani Eva Heredero Gálvez Carolina Maicas Bellido José Largo Pau Mª Antonia Sepúlveda Pilar Toledano Sierra Sadaf Zafar Iqbal-Mirza Eva Cascales Alcolea Pilar Egea Serrano José Joaquín Hernández Roca
* Auteur correspondant
Abstract : Background: Prosthetic valve endocarditis caused by Candida spp. (PVE-C) is rare and devastating, with international guidelines based on expert recommendations supporting the combination of surgery and subsequent azole treatment. Methods: We retrospectively analyzed PVE-C cases collected in Spain and France between 2001 and 2015, with a focus on management and outcome. Results: Forty-six cases were followed up for a median of 9 months. Twenty-two patients (48%) had a history of endocarditis, 30 cases (65%) were nosocomial or healthcare related, and 9 (20%) patients were intravenous drug users. "Induction" therapy consisted mainly of liposomal amphotericin B (L-amB)-based (n = 21) or echinocandin-based therapy (n = 13). Overall, 19 patients (41%) were operated on. Patients <66 years old and without cardiac failure were more likely to undergo cardiac surgery (adjusted odds ratios [aORs], 6.80 [95% confidence interval [CI], 1.59-29.13] and 10.92 [1.15-104.06], respectively). Surgery was not associated with better survival rates at 6 months. Patients who received L-amB alone had a better 6-month survival rate than those who received an echinocandin alone (aOR, 13.52; 95% CI, 1.03-838.10). "Maintenance" fluconazole therapy, prescribed in 21 patients for a median duration of 13 months (range, 2-84 months), led to minor adverse effects. Conclusion: L-amB induction treatment improves survival in patients with PVE-C. Medical treatment followed by long-term maintenance fluconazole may be the best treatment option for frail patients.
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https://hal.univ-angers.fr/hal-02407034
Contributeur : Nathalie Clement <>
Soumis le : jeudi 12 décembre 2019 - 12:32:07
Dernière modification le : mercredi 14 octobre 2020 - 04:16:39

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Claire Rivoisy, Antonio Vena, Laura Schaeffer, Caroline Charlier, Arnaud Fontanet, et al.. Prosthetic Valve Candida spp. Endocarditis: New Insights Into Long-term Prognosis—The ESCAPE Study. Clinical Infectious Diseases, Oxford University Press (OUP), 2018, 66 (6), pp.825-832. ⟨10.1093/cid/cix913⟩. ⟨hal-02407034⟩

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