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Identification of aqueous reservoirs in poly(alkylcyanoacrylate) nanoparticles

Abstract : Poly (n-butylcyanocrylate) nanocapsules were obtained by interfacial polymerization from a water-in-oil microemulsion. The latter was composed of pharmaceutically acceptable excipients such as Labrafac lipophile WL 1349 (oil), Plurol oleique CC497 (surfactant), and Labrasol (co-surfactant) and was able to incorporate 20% aqueous phase. Pure n-butylcyanoacrylate monomer (without any dilution in a halogenated solvent) was added to the microemulsion in order to obtain an oily suspension of biocompatible and biodegradable aqueous core nanocapsules. Finally, in order to provide a direct evidence of the presence of water within the nanocapsules, a mass balance and nuclear magnetic resonance analysis were performed. The results showed that the presence of water and transmission electronic microscopy confirmed a hybrid structure of the final nanosystem, between a genuine nanocapsule and a matrix system: a nanosystem with multicavities filled with water.
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https://hal.univ-angers.fr/hal-02430652
Contributeur : Olivier Thomas <>
Soumis le : vendredi 6 mars 2020 - 13:30:01
Dernière modification le : lundi 9 mars 2020 - 10:38:04
Archivage à long terme le : : dimanche 7 juin 2020 - 14:39:19

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O. Thomas, L. Lemaire, J. Benoit, P. Saulnier. Identification of aqueous reservoirs in poly(alkylcyanoacrylate) nanoparticles. Colloid and Polymer Science, Springer Verlag, 2020, 298 (2), pp.203-212. ⟨10.1007/s00396-019-04593-4⟩. ⟨hal-02430652⟩

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