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Matrix-Free Laser Desorption Ionization Mass Spectrometry as an Efficient Tool for the Rapid Detection of Opiates in Crude Extracts of Papaver somniferum

Abstract : Having a long history of traditional medicinal applications, Papaver somniferum is also known as a source of various pharmacologically highly active opiates. Consequently, their detection from plant extracts is an important analytical task and generally addressed by methods of GC−MS and LC–MS. However, opiates do also show structural similarities to matrix molecules used in matrix-assisted laser desorption ionization (LDI) and may therefore ionize upon simple laser irradiation. Following this analytical approach, the present work thoroughly evaluated the direct detection of opiates by matrix-free LDI in crude extracts of P. somniferum. The method facilitated the identification of 10 reported opiates by their molecular formulas without any chromatographic prepurification. Moreover, a principal component analysis based on LDI-MS data permitted the correct grouping of all extracts according to their inherent chemistry. Concluding experiments on serial dilutions of thebaine further evaluated potential quantitative applications of the method. Overall results highlight the promising potential of LDI-MS for the swift detection of opiates in complex mixtures.
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https://hal.univ-angers.fr/hal-02452615
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Soumis le : vendredi 23 septembre 2022 - 09:19:11
Dernière modification le : lundi 14 novembre 2022 - 01:06:08

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Michaela Skopikova, Masahiro Hashimoto, Pascal Richomme, Andreas Schinkovitz. Matrix-Free Laser Desorption Ionization Mass Spectrometry as an Efficient Tool for the Rapid Detection of Opiates in Crude Extracts of Papaver somniferum. Journal of Agricultural and Food Chemistry, 2020, 68 (3), pp.884-891. ⟨10.1021/acs.jafc.9b05153⟩. ⟨hal-02452615⟩

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