Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model
UA - Université d'Angers : EA3142 (Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01 - France)
Abstract : Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.
https://hal.univ-angers.fr/hal-02483291 Contributeur : Nathalie ClementConnectez-vous pour contacter le contributeur Soumis le : mercredi 19 février 2020 - 17:16:11 Dernière modification le : jeudi 7 avril 2022 - 10:10:26 Archivage à long terme le : : mercredi 20 mai 2020 - 16:34:46
Sarah Sze Wah Wong, Vadim Krylov, Dmitry Argunov, Alexander Karelin, Jean-Phillipe Bouchara, et al.. Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model. MSphere, American Society for Microbiology., 2020, 5 (1), pp.e00688-19. ⟨10.1128/mSphere.00688-19⟩. ⟨hal-02483291⟩