Accéder directement au contenu Accéder directement à la navigation

Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study

Abstract : Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25-hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25OHD = 67.3 ± 20.8 nmol/L). Gray matter volume (GMV) was automatically segmented using voxel-based morphometry with CAT12 software. Covariables were age, gender, education, total intracranial volume, and season. Serum 25OHD was positively associated with GMV in left calcarine sulcus (P < 0.05, TFCE, FWE-corrected). We found atrophy of the calcarine sulcus with lower 25OHD concentrations in older adults. © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-02510288
Contributeur : Marie-Françoise Gerard <>
Soumis le : mardi 17 mars 2020 - 16:13:35
Dernière modification le : mercredi 18 mars 2020 - 01:35:08

Lien texte intégral

Identifiants

Collections

Citation

Pauline Ali, Matthieu Labriffe, Nastassia Navasiolava, Marc‐antoine Custaud, Mickaël Dinomais, et al.. Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study. Annals of Clinical and Translational Neurology, Wiley, 2020, ⟨10.1002/acn3.50997⟩. ⟨hal-02510288⟩

Partager

Métriques

Consultations de la notice

32