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Article dans une revue

Concise semisynthesis of novel phenazine-vitamin E hybrids via regioselective tocopheryl ortho-quinone formation

Abstract : A regioselective method for the semisynthesis of phenazine derivatives has been disclosed through an efficient IBX mediated ortho-quinone formation from vitamin E derivatives. High chemo- and regio-selectivity was observed during the oxidation step and the corresponding 5,6-ortho-quinones could react with various phenylenediamines. Thus, this methodology proves its interest as a concise semisynthetic pathway to phenazine-vitamin E hybrids with moderate to good yields.
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https://hal.univ-angers.fr/hal-02521254
Contributeur : Okina Université d'Angers <>
Soumis le : vendredi 27 mars 2020 - 12:18:15
Dernière modification le : samedi 28 mars 2020 - 02:27:02

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Guillaume Viault, Jean-Jacques Helesbeux, Pascal Richomme, Denis Seraphin. Concise semisynthesis of novel phenazine-vitamin E hybrids via regioselective tocopheryl ortho-quinone formation. Tetrahedron Letters, 2018, 59 (27), pp.2627-2630. ⟨10.1016/j.tetlet.2018.05.011⟩. ⟨hal-02521254⟩

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