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Article dans une revue

Inhibitory effects of Blackstonia grandiflora extracts on the formation of advanced glycation end products (AGEs)

Abstract : Glycation, the nonenzymatic reaction of reducing sugars with amino groups, is increased in hyperglycemic physiological environments, leading to an acceleration of the formation of advanced glycation end products (AGEs). The AGEs are associated with many pathogenic disorders such as Alzheimer’s disease, pathogenesis of diabetes, and atherosclerosis. They are also responsible for aging and tissue damage. In this study, the antiglycation activity of the extracts Blackstonia grandiflora (Viv.) was evaluated in the bovine serum albumin (BSA)/ribose system and the potency of these extracts was compared with the standard antiglycation agent aminoguanidine. The results showed that EtOAc extract had a significant inhibitory effect on the formation of advanced glycation end products (AGEs).
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Article dans une revue
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https://hal.univ-angers.fr/hal-02521257
Contributeur : Okina Université d'Angers <>
Soumis le : vendredi 27 mars 2020 - 12:18:21
Dernière modification le : jeudi 2 juillet 2020 - 03:29:21

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  • HAL Id : hal-02521257, version 1
  • OKINA : ua15412

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Fatima Zohra Belfadel, Kamel Medjroubi, Salah Akkal, Séverine Derbré, Elisabeth Seguin. Inhibitory effects of Blackstonia grandiflora extracts on the formation of advanced glycation end products (AGEs). Der Pharma Chemica, Der Pharma Chemica, 2016, 15 (8), pp.146-149. ⟨hal-02521257⟩

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