Insecticides were used as pest management tools for a long time. The appearance of resistant insects has led the scientific community to rethink their use and to study the mechanisms underlying the resistance in order to circumvent it. However, we know now that sublethal doses of insecticide induce many effects which should be taken into account for pest control. In this review, we summarized current knowledge on mechanisms used by insects to deal with exposure to sublethal dose of insecticides. Physiological and cellular changes could contribute to the adaptation of the insect to its environment making the challenge of managing pests difficult.