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Perinatal stroke syndromes: Similarities and diversities in aetiology, outcome and management

Abstract : With a birth-prevalence of 37-67/100,000 (mostly term-born), perinatal stroke encompasses distinct disease-states with diverse causality, mechanism, time of onset, mode of presentation and outcome. Neonatal primary haemorrhagic stroke and ischemic events (also divided into neonatal arterial ischemic stroke and neonatal cerebral sinus venous thrombosis) that manifest soon after birth are distinguished from presumed perinatal - ischemic or haemorrhagic - stroke. Signs of the latter become apparent only beyond the neonatal period, most often with motor asymmetry or milestones delay, and occasionally with seizures. Acute or remote MRI defines the type of stroke and is useful for prognosis. Acute care relies on homeostatic maintenance. Seizures are often self-limited and anticonvulsant agents might be discontinued before discharge. Prolonged anticoagulation for a few weeks is an option in some cases of sinovenous thrombosis. Although the risk of severe impairment is low, many children develop mild to moderate multimodal developmental issues that require a multidisciplinary approach.
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Soumis le : lundi 25 octobre 2021 - 10:44:47
Dernière modification le : lundi 14 novembre 2022 - 02:46:05
Archivage à long terme le : : mercredi 26 janvier 2022 - 19:06:14


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Joel Fluss, Mickaël Dinomais, Stéphane Chabrier. Perinatal stroke syndromes: Similarities and diversities in aetiology, outcome and management. European Journal of Paediatric Neurology, 2019, 23 (3), pp.368-383. ⟨10.1016/j.ejpn.2019.02.013⟩. ⟨hal-02535039⟩



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