Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Models for drug absorption from the small intestine: where are we and where are we going?

Abstract :

The small intestine is a complex organ with movements, flora, mucus and flows. Despite this, the most widely used absorption models consider the organ a cylindrical monoepithelial tube. This review presents the recent evolution of models to take into consideration the complex nature of gut physiology. The most commonly encountered issues are ethical (in vivo models) and differences in drug transport as a result of a modified expression of drug transporters or metabolic enzymes compared with human (in vitro and in vivo models). Finally, this review discusses the way forward to reach an ideal equilibrium between reproducibility, predictability and efficiency for predicting permeability. The features of an ideal model are listed as a guideline for future development.

Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-02615955
Contributeur : Okina Université d'Angers <>
Soumis le : dimanche 24 mai 2020 - 01:53:33
Dernière modification le : mercredi 27 mai 2020 - 03:58:45

Identifiants

Collections

Citation

Pierre-André Billat, Emilie Roger, Sébastien Faure, Frédéric Lagarce. Models for drug absorption from the small intestine: where are we and where are we going?. Drug Discovery Today, Elsevier, 2017, 22 (5), pp.761-775. ⟨10.1016/j.drudis.2017.01.007⟩. ⟨hal-02615955⟩

Partager

Métriques

Consultations de la notice

12