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Poster De Conférence Année : 2017

Enhanced internalization of lipid nanocapsules in human glioblastoma cells: Influence of the concentration of surface-functionalizing NFL peptide

Reatul Karim
  • Fonction : Auteur
  • PersonId : 1070050
Elise Lepeltier
Claudio Palazzo
  • Fonction : Auteur
Brigitte Evrard
  • Fonction : Auteur
Joël Eyer
  • Fonction : Auteur
  • PersonId : 860664

Résumé

Glioblastoma multiforme (GBM) patients have median survival of 14 months after current treatments. Therefore, more efficacious therapies are necessary. Lipid nanocapsules (LNC) functionalized with NFL.TBS-40.63 peptide (NFL) showed enhanced internalization in mouse GBM cells. The aim of the study was to evaluate the effect of the surface-functionalizing FAM-NFL (fluoNFL) concentrations on LNC uptake in U87MG human GBM cells. A ferrocifen-type anticancer molecule (FcTriOH) was encapsulated in the nanocarriers and their in vitro efficacy on U87MG cells was evaluated. Finally, in vivo antitumor effect of the formulations were evaluated in ectopic U87MG tumor model in mice.

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Dates et versions

hal-02615982 , version 1 (24-05-2020)

Identifiants

  • HAL Id : hal-02615982 , version 1
  • OKINA : ua16274

Citer

Reatul Karim, Elise Lepeltier, Claudio Palazzo, Claire Lépinoux-Chambaud, Brigitte Evrard, et al.. Enhanced internalization of lipid nanocapsules in human glioblastoma cells: Influence of the concentration of surface-functionalizing NFL peptide. 21st International Symposium on Microencapsulation, 2017, Faro, Portugal. , 2017. ⟨hal-02615982⟩
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