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Enhanced internalization of lipid nanocapsules in human glioblastoma cells: Influence of the concentration of surface-functionalizing NFL peptide

Abstract :

Glioblastoma multiforme (GBM) patients have median survival of 14 months after current treatments. Therefore, more efficacious therapies are necessary. Lipid nanocapsules (LNC) functionalized with NFL.TBS-40.63 peptide (NFL) showed enhanced internalization in mouse GBM cells. The aim of the study was to evaluate the effect of the surface-functionalizing FAM-NFL (fluoNFL) concentrations on LNC uptake in U87MG human GBM cells. A ferrocifen-type anticancer molecule (FcTriOH) was encapsulated in the nanocarriers and their in vitro efficacy on U87MG cells was evaluated. Finally, in vivo antitumor effect of the formulations were evaluated in ectopic U87MG tumor model in mice.

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https://hal.univ-angers.fr/hal-02615982
Contributeur : Okina Univ Angers Connectez-vous pour contacter le contributeur
Soumis le : dimanche 24 mai 2020 - 02:50:18
Dernière modification le : vendredi 7 janvier 2022 - 03:47:49

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  • HAL Id : hal-02615982, version 1
  • OKINA : ua16274

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Reatul Karim, Elise Lepeltier, Claudio Palazzo, Claire Lépinoux-Chambaud, Brigitte Evrard, et al.. Enhanced internalization of lipid nanocapsules in human glioblastoma cells: Influence of the concentration of surface-functionalizing NFL peptide. 21st International Symposium on Microencapsulation, 2017, Faro, Portugal. , 2017. ⟨hal-02615982⟩

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