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Penta-block copolymer microspheres: Impact of polymer characteristics and process parameters on protein release

Abstract :

Here, we aimed to develop protein loaded microspheres (MSs) using penta-block PLGA-based copolymers to obtain sustained and complete protein release. We varied MS morphology and studied the control of protein release. Lysozyme was used as a model protein and MSs were prepared using the solid-in-oil-in-water emulsion solvent extraction method. We synthesized and studied various penta-block PLGA-based copolymers. Copolymer characteristics (LA/GA ratio and molecular weight of PLGA blocks) influenced MS morphology. MS porosity was influenced by process parameters (such as solvent type, polymer concentration, emulsifying speed), whereas the aqueous volume for extraction and stabilizer did not have a significant effect. MSs of the same size, but different morphologies, exhibited different protein release behavior, with porous structures being essential for the continuous and complete release of encapsulated protein. These findings suggest strategies to engineer the morphology of MSs produced from PLGA-based multi-block copolymers to achieve appropriate release rates for a protein delivery system.

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Article dans une revue
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https://hal.univ-angers.fr/hal-02616041
Contributeur : Okina Université d'Angers <>
Soumis le : dimanche 24 mai 2020 - 03:40:26
Dernière modification le : mercredi 27 mai 2020 - 04:08:59

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Minh Quan Le, Fabien Violet, Cédric Paniagua, Xavier Garric, Marie-Claire Venier-Julienne. Penta-block copolymer microspheres: Impact of polymer characteristics and process parameters on protein release. International Journal of Pharmaceutics, Elsevier, 2018, 535 (1-2), pp.428-437. ⟨10.1016/j.ijpharm.2017.11.033⟩. ⟨hal-02616041⟩

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