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Article dans une revue

Neurofilaments form flexible bundles during neuritogenesis in culture and in mature axons in situ

Abstract :

Neurofilaments (NFs) undergo cation-dependent phospho-mediated associations with each other and other cytoskeletal elements that support axonal outgrowth. Progressive NF-NF associations generate a resident, bundled population that undergoes exchange with transporting NFs. We examined the properties of bundled NFs. Bundles did not always display a fully linear profile but curved and twisted at various points along the neurite length. Bundles retracted faster than neurites and retracted bundles did not expand following extraction with Triton, indicating that they coiled passively rather than due to pressure from the cell. Bundles consisted of helically wound NFs, which may provide flexibility necessary for turning of growing axons during pathfinding. Interactions between NFs and other cytoskeletal elements may be disrupted en masse during neurite retraction or regionally during remodeling. It is suggested that bundles within long axons that cannot be fully retracted into the soma could provide maintain proximal support yet still allow more distal flexibility for remodeling and changing direction during pathfinding.

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Article dans une revue
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Soumis le : dimanche 24 mai 2020 - 04:34:29
Dernière modification le : mardi 4 janvier 2022 - 05:59:52




Sangmook Lee, Joël Eyer, Franck Letournel, Edward Boumil, Garth Hall, et al.. Neurofilaments form flexible bundles during neuritogenesis in culture and in mature axons in situ. Journal of neuroscience research, 2019, 97 (10), pp.1306-1318. ⟨10.1002/jnr.24482⟩. ⟨hal-02616071⟩



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