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Dodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency

Abstract :

Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations of CrT. This work focus on the preclinical development of a new therapeutic approach based on a microemulsion (ME) as drug delivery system for dodecyl creatine ester (DCE). DCE-ME was prepared by titration method. Novel object recognition (NOR) tests were performed before and after DCE-ME treatment on mice. Intranasal administration with DCE-ME improved NOR performance in mice. mice treated with DCE-ME had increased striatal ATP levels mainly in the striatum compared with vehicle-treated mice which was associated with increased expression of synaptic markers. These results highlight the potential value of DCE-ME as promising therapy for creatine transporter deficiency.

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Article dans une revue
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https://hal.univ-angers.fr/hal-02616077
Contributeur : Okina Université d'Angers <>
Soumis le : dimanche 24 mai 2020 - 04:34:46
Dernière modification le : mercredi 19 août 2020 - 11:18:02

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Gabriela Veroniva Ullio Gamboa, Kenea Udobi, Sophie Dézard, Marla Perna, Keila Miles, et al.. Dodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency. Nanomedicine (London, England), 2019, 14 (12), pp.1579-1593. ⟨10.2217/nnm-2019-0059⟩. ⟨hal-02616077⟩

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