![]() |
Gabriela Veroniva Ullio Gamboa 1
Auteur
Kenea Udobi 2
Auteur
Sophie Dézard 3
Auteur
Marla Perna 2
Auteur
Jean-Pierre Benoit 7
Auteur
Matthew Skelton 2
Auteur
Pascale de Lonlay 8
Auteur
Aloïse Mabondzo 9
Auteur correspondant
Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations of CrT. This work focus on the preclinical development of a new therapeutic approach based on a microemulsion (ME) as drug delivery system for dodecyl creatine ester (DCE). DCE-ME was prepared by titration method. Novel object recognition (NOR) tests were performed before and after DCE-ME treatment on mice. Intranasal administration with DCE-ME improved NOR performance in mice. mice treated with DCE-ME had increased striatal ATP levels mainly in the striatum compared with vehicle-treated mice which was associated with increased expression of synaptic markers. These results highlight the potential value of DCE-ME as promising therapy for creatine transporter deficiency.
UNIV-ANGERS | CEA | CEA-UPSAY | INC-CNRS | JOLIOT | DMTS | CNRS | MINT | CEA-DRF | UNIV-PARIS-SACLAY | UNIV-PARIS | INRAE | GS-HEALTH-DRUG-SCIENCES