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Review of Clinical Trials Using Neural Stem Cells

Abstract :

The use of stem cells in clinical trials started several years ago for regenerativebased therapies or for the treatment of tumours. After brain injuries or neurodegenerative diseases, neural stem cells represent a promising strategy to repair the affected tissue and to replace degenerative cells. Neural stem cells can migrate and differentiate into neurons, astrocytes and oligodendrocytes, and thus could serve as promising therapeutic solutions. However, these cells can represent a potential source of cancer stem cells in tumour brain where they are responsible of recurrence, invasiveness and resistance to current treatments. Thus, few clinical trials involving endogenous, genetically modifiedor derived-neural stem cells have been conducted in the world to treat brain disorders. According to the website only 37 clinical trials involving neural stem cells are listed. Most of them use derived-neural stem cells to treat brain disorders (neurodegenerative diseases, injuries or tumours). For the future, a better approach would be to target directly endogenous stem cells. 

Type de document :
Article dans une revue
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Contributeur : Okina Université d'Angers <>
Soumis le : dimanche 24 mai 2020 - 15:40:17
Dernière modification le : mercredi 14 octobre 2020 - 04:17:12


  • HAL Id : hal-02616335, version 1
  • OKINA : ua15255



Kristell Barreau, Claire Lépinoux-Chambaud, Eyer Joël. Review of Clinical Trials Using Neural Stem Cells. JSM Biotechnology and Biomedical Engineering, 2016, 3 (3), Non spécifié. ⟨hal-02616335⟩



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