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Article dans une revue

Patient Blood Management in Major Orthopedic Surgery: Less Erythropoietin and More Iron?

Abstract :

Erythropoietin (EPO) is proposed preoperatively to reduce blood transfusion in anemic patients (hemoglobin < 13 g/dL) scheduled for a major orthopedic surgery. New intravenous iron formulations allow infusion of higher doses, increasing EPO response. In that context, we evaluated in a before-after study (n = 62 and 65 patients for each period) a new EPO administration protocol (2 injections 4 and 3 weeks before surgery, and a third if hemoglobin <13 g/dL instead of <15 g/dL 2 weeks before surgery). After this protocol implementation, the mean (standard deviation) number of EPO injections decreased from 2.8 (0.5) to 2.2 (0.4)/patient (P < .0001) without changing transfusion rates (3% in the 2 periods).

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Article dans une revue
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https://hal.univ-angers.fr/hal-02616848
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 25 mai 2020 - 01:49:20
Dernière modification le : lundi 25 mai 2020 - 03:20:34

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Emmanuel Rineau, Alexandra Stoyanov, Emmanuel Samson, Laurent Hubert, Sigismond Lasocki. Patient Blood Management in Major Orthopedic Surgery: Less Erythropoietin and More Iron?. Anesthesia and Analgesia, Lippincott, Williams & Wilkins, 2017, 125 (5), pp.1597-1599. ⟨10.1213/ANE.0000000000002086⟩. ⟨hal-02616848⟩

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