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Clinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation

Karine Renaudin 1 Sarra Smati 2, 3 Matthieu Wargny 2, 3 Abir Al Ghuzlan 4 Sébastien Aubert 5 Emmanuelle Leteurtre 6, 7, 5 Martine Patey 8 Mathilde Sibony 9 Nathalie Sturm 10, 11 Frédérique Tissier 12 Laurence Amar 13 Jerome Bertherat 14 Claudine Berthozat 15 Olivier Chabre 16 Christine Do Cao 17 Magalie Haissaguerre 18 Peggy Pierre 19 Claire Briet 20 Delphine Vezzosi 21 Jean-Christophe Lifante 22, 23, 24 François Pattou 25 Eric Mirallié 26 Eric Baudin 27 Bertrand Cariou 2 Rossella Libé 28, 29, 30 Delphine Drui 31, 2
27 Médecine nucléaire
Département d'imagerie médicale [Gustave Roussy]
Abstract :

Oncocytic adrenocortical tumors are a rare subtype of adrenal tumors with challenging diagnosis and histoprognostic assessment. It is usually believed that oncocytic adrenocortical tumors have a more indolent clinical behavior than conventional adrenocortical tumors. As the Weiss score overestimates the malignancy of oncocytic adrenocortical tumors owing to intrinsic parameters, alternative scores have been proposed. The Lin-Weiss-Bisceglia score is currently recommended. We performed a large nationwide multicenter retrospective clinicopathologic study of oncocytic adrenocortical tumors. Among the 43 patients in our cohort, 40 patients were alive without disease, 2 patients died of their disease and 1 patient was alive with relapse after a median follow-up of 38 months (20-59). Our data revealed that over 50% of the oncocytic adrenocortical tumor cases were diagnosed as carcinoma whatever the classification systems used, including the Lin-Weiss-Bisceglia score. The exception is the Helsinki score, which incorporates the Ki-67 proliferation index and was the most specific prognostic score for oncocytic adrenocortical tumor malignancy without showing a loss in sensitivity. A comparison of malignant oncocytic adrenocortical tumors with conventional adrenocortical carcinomas matched for age, sex, ENS@T stage and surgical resection status showed significant better overall survival of malignant oncocytic adrenocortical tumors.

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https://hal.univ-angers.fr/hal-02616865
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 25 mai 2020 - 01:55:45
Dernière modification le : mardi 20 octobre 2020 - 03:14:07

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Karine Renaudin, Sarra Smati, Matthieu Wargny, Abir Al Ghuzlan, Sébastien Aubert, et al.. Clinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation. Modern pathology, 2018, 31, pp.1708-1716. ⟨10.1038/s41379-018-0077-8⟩. ⟨hal-02616865⟩

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