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Clinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation

Karine Renaudin 1 Sarra Smati 2, 3 Matthieu Wargny 2, 3 Abir Al Ghuzlan 4 Sébastien Aubert 5 Emmanuelle Leteurtre 6, 7, 5 Martine Patey 8 Mathilde Sibony 9 Nathalie Sturm 10, 11 Frédérique Tissier 12 Laurence Amar 13 Jerome Bertherat 14 Claudine Berthozat 15 Olivier Chabre 16 Christine Do Cao 17 Magalie Haissaguerre 18 Peggy Pierre 19 Claire Briet 20 Delphine Vezzosi 21 Jean-Christophe Lifante 22, 23, 24 François Pattou 25 Eric Mirallié 26 Eric Baudin 27 Bertrand Cariou 2 Rossella Libé 28, 29, 30 Delphine Drui 31, 2
1 Service de Pathologie [CHU Nantes]
2 ITX - unité de recherche de l'institut du thorax UMR1087 UMR6291
3 CIC Nantes - Centre d’Investigation Clinique de Nantes
4 Département de biologie et pathologie médicales [Gustave Roussy]
5 Service de pathologie [CHU Lille]
6 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837
7 SIRIC-ONCOLille - Site de Recherche Intégrée en Cancérologie
8 Laboratoire d’anatomie et cytologie pathologique, Hôpital Robert Debré, CHU de Reims
9 Service d'anatomie pathologique [CHU Tenon]
10 Département de Gastroentérologie et hépatologie
11 CHU Grenoble Alpes - Centre Hospitalier Universitaire Grenoble Alpes
12 UP4 - Université Paris-Sorbonne
13 Hypertension Unit, hôpital Européen-Georges-Pompidou
14 Service d'Endocrinologie
15 UGA UFRM - Université Grenoble Alpes - UFR Médecine
16 Service d'endocrinologie-diabétologie-nutrition [CHU Grenoble-Alpes]
17 Service d’endocrinologie, diabétologie et maladies métaboliques [CHRU LIlle]
18 Département d'endocrinologie - Bordeaux 2
19 TOURS - Endocrino - Service d'Endocrinologie
20 MITOVASC - Physiopathologie Cardiovasculaire et Mitochondriale
21 TOULOUSE - Endocrino - Service d'Endocrinologie
22 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
23 Service de Chirurgie Générale et Endocrinienne [Lyon]
24 HESPER - Health Service and Performance Research
25 Service de chirurgie générale et endocrinienne
26 Service de Chirurgie Digestive et Endocrinienne [Nantes]
27 Médecine nucléaire
Département d'imagerie médicale [Gustave Roussy]
28 Hôpital Cochin [AP-HP]
29 IC UM3 (UMR 8104 / U1016) - Institut Cochin
30 UPD5 - Université Paris Descartes - Paris 5
31 Service d'Endocrinologie [Nantes]
Abstract :

Oncocytic adrenocortical tumors are a rare subtype of adrenal tumors with challenging diagnosis and histoprognostic assessment. It is usually believed that oncocytic adrenocortical tumors have a more indolent clinical behavior than conventional adrenocortical tumors. As the Weiss score overestimates the malignancy of oncocytic adrenocortical tumors owing to intrinsic parameters, alternative scores have been proposed. The Lin-Weiss-Bisceglia score is currently recommended. We performed a large nationwide multicenter retrospective clinicopathologic study of oncocytic adrenocortical tumors. Among the 43 patients in our cohort, 40 patients were alive without disease, 2 patients died of their disease and 1 patient was alive with relapse after a median follow-up of 38 months (20-59). Our data revealed that over 50% of the oncocytic adrenocortical tumor cases were diagnosed as carcinoma whatever the classification systems used, including the Lin-Weiss-Bisceglia score. The exception is the Helsinki score, which incorporates the Ki-67 proliferation index and was the most specific prognostic score for oncocytic adrenocortical tumor malignancy without showing a loss in sensitivity. A comparison of malignant oncocytic adrenocortical tumors with conventional adrenocortical carcinomas matched for age, sex, ENS@T stage and surgical resection status showed significant better overall survival of malignant oncocytic adrenocortical tumors.

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https://hal.univ-angers.fr/hal-02616865
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 25 mai 2020 - 01:55:45
Dernière modification le : mercredi 26 mai 2021 - 19:56:03

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UNIV-ANGERS | HCL | CHLS | LAMBRET | FNCLCC | UNIV-LILLE3 | UNIV-LYON1 | UNIV-NANTES | THORAX-UMR | CNRS | UDL | UNIV-PARIS5 | UP-SANTE | MITOVASC | USPC | SORBONNE-UNIVERSITE | UNIV-PARIS | IGR | UNIV-LILLE | UGA | SU-TI

Citation

Karine Renaudin, Sarra Smati, Matthieu Wargny, Abir Al Ghuzlan, Sébastien Aubert, et al.. Clinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation. Modern pathology, 2018, 31, pp.1708-1716. ⟨10.1038/s41379-018-0077-8⟩. ⟨hal-02616865⟩

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