Clinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation

Karine Renaudin; Sarra Smati; Matthieu Wargny; Abir Al Ghuzlan; Sébastien Aubert; Emmanuelle Leteurtre; Martine Patey; Mathilde Sibony; Nathalie Sturm; Frédérique Tissier; Laurence Amar; Jerome Bertherat; Claudine Berthozat; Olivier Chabre; Christine Do Cao; Magalie Haissaguerre; Peggy Pierre; Claire Briet; Delphine Vezzosi; Jean-Christophe Lifante; François Pattou; Eric Mirallié; Eric Baudin; Bertrand Cariou; Rossella Libé; Delphine Drui

doi:10.1038/s41379-018-0077-8

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Clinicopathological description of 43 oncocytic adrenocortical tumors: importance of Ki-67 in histoprognostic evaluation

Karine Renaudin ¹ Sarra Smati ^{2, 3} Matthieu Wargny ^{2, 3} Abir Al Ghuzlan ⁴ Sébastien Aubert ⁵ Emmanuelle Leteurtre ^{6, 7, 5} Martine Patey ⁸ Mathilde Sibony ⁹ Nathalie Sturm ^{10, 11} Frédérique Tissier ¹² Laurence Amar ¹³ Jerome Bertherat ¹⁴ Claudine Berthozat ¹⁵ Olivier Chabre ¹⁶ Christine Do Cao ¹⁷ Magalie Haissaguerre ¹⁸ Peggy Pierre ¹⁹ Claire Briet ²⁰ Delphine Vezzosi ²¹ Jean-Christophe Lifante ^{22, 23, 24} François Pattou ²⁵ Eric Mirallié ²⁶ Eric Baudin ²⁷ Bertrand Cariou ² Rossella Libé ^{28, 29, 30} Delphine Drui ^{31, 2}

1 Service de Pathologie [CHU Nantes]

2 ITX - unité de recherche de l'institut du thorax UMR1087 UMR6291

3 CIC Nantes - Centre d’Investigation Clinique de Nantes

4 Département de biologie et pathologie médicales [Gustave Roussy]

5 Service de pathologie [CHU Lille]

6 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837

7 SIRIC-ONCOLille - Site de Recherche Intégrée en Cancérologie

8 Laboratoire d’anatomie et cytologie pathologique, Hôpital Robert Debré, CHU de Reims

9 Service d'anatomie pathologique [CHU Tenon]

10 Département de Gastroentérologie et hépatologie

11 CHU - Centre Hospitalier Universitaire [Grenoble]

12 UP4 - Université Paris-Sorbonne

13 Service d'HYPERVASC [CHU HEGP)

14 Service d'Endocrinologie

15 UGA UFRM - Université Grenoble Alpes - UFR Médecine

16 Service d'endocrinologie-diabétologie-nutrition [CHU Grenoble-Alpes]

17 Service d’endocrinologie, diabétologie et maladies métaboliques [CHRU LIlle]

18 Département d'endocrinologie - Bordeaux 2

19 TOURS - Endocrino - Service d'Endocrinologie

20 MITOVASC - Physiopathologie Cardiovasculaire et Mitochondriale

21 TOULOUSE - Endocrino - Service d'Endocrinologie

22 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]

23 Service de Chirurgie Générale et Endocrinienne [Lyon]

24 HESPER - Health Service and Performance Research

25 Service de chirurgie générale et endocrinienne

26 Service de Chirurgie Digestive et Endocrinienne [Nantes]

27 Médecine nucléaire

Département d'imagerie médicale [Gustave Roussy]

28 Hôpital Cochin [AP-HP]

29 IC UM3 (UMR 8104 / U1016) - Institut Cochin

30 UPD5 - Université Paris Descartes - Paris 5

31 Service d'Endocrinologie [Nantes]

Abstract :

Oncocytic adrenocortical tumors are a rare subtype of adrenal tumors with challenging diagnosis and histoprognostic assessment. It is usually believed that oncocytic adrenocortical tumors have a more indolent clinical behavior than conventional adrenocortical tumors. As the Weiss score overestimates the malignancy of oncocytic adrenocortical tumors owing to intrinsic parameters, alternative scores have been proposed. The Lin-Weiss-Bisceglia score is currently recommended. We performed a large nationwide multicenter retrospective clinicopathologic study of oncocytic adrenocortical tumors. Among the 43 patients in our cohort, 40 patients were alive without disease, 2 patients died of their disease and 1 patient was alive with relapse after a median follow-up of 38 months (20-59). Our data revealed that over 50% of the oncocytic adrenocortical tumor cases were diagnosed as carcinoma whatever the classification systems used, including the Lin-Weiss-Bisceglia score. The exception is the Helsinki score, which incorporates the Ki-67 proliferation index and was the most specific prognostic score for oncocytic adrenocortical tumor malignancy without showing a loss in sensitivity. A comparison of malignant oncocytic adrenocortical tumors with conventional adrenocortical carcinomas matched for age, sex, ENS@T stage and surgical resection status showed significant better overall survival of malignant oncocytic adrenocortical tumors.

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https://hal.univ-angers.fr/hal-02616865
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Soumis le : lundi 25 mai 2020 - 01:55:45
Dernière modification le : mercredi 27 avril 2022 - 03:50:40

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