![]() |
Karine Renaudin 1
Auteur
Sarra Smati 2, 3
Auteur
Matthieu Wargny 2, 3
Auteur
Abir Al Ghuzlan 4
Auteur
Sébastien Aubert 5
Auteur
Emmanuelle Leteurtre 6, 7, 5
Auteur
Martine Patey 8
Auteur
Mathilde Sibony 9
Auteur
Nathalie Sturm 10, 11
Auteur
Frédérique Tissier 12
Auteur
Laurence Amar 13
Auteur
Jerome Bertherat 14
Auteur
Claudine Berthozat 15
Auteur
Olivier Chabre 16
Auteur
Christine Do Cao 17
Auteur
Magalie Haissaguerre 18
Auteur
Peggy Pierre 19
Auteur
Claire Briet 20
Auteur
Delphine Vezzosi 21
Auteur
Jean-Christophe Lifante 22, 23, 24
Auteur
Rossella Libé 28, 29, 30
Auteur
Delphine Drui 31, 2
Auteur
Oncocytic adrenocortical tumors are a rare subtype of adrenal tumors with challenging diagnosis and histoprognostic assessment. It is usually believed that oncocytic adrenocortical tumors have a more indolent clinical behavior than conventional adrenocortical tumors. As the Weiss score overestimates the malignancy of oncocytic adrenocortical tumors owing to intrinsic parameters, alternative scores have been proposed. The Lin-Weiss-Bisceglia score is currently recommended. We performed a large nationwide multicenter retrospective clinicopathologic study of oncocytic adrenocortical tumors. Among the 43 patients in our cohort, 40 patients were alive without disease, 2 patients died of their disease and 1 patient was alive with relapse after a median follow-up of 38 months (20-59). Our data revealed that over 50% of the oncocytic adrenocortical tumor cases were diagnosed as carcinoma whatever the classification systems used, including the Lin-Weiss-Bisceglia score. The exception is the Helsinki score, which incorporates the Ki-67 proliferation index and was the most specific prognostic score for oncocytic adrenocortical tumor malignancy without showing a loss in sensitivity. A comparison of malignant oncocytic adrenocortical tumors with conventional adrenocortical carcinomas matched for age, sex, ENS@T stage and surgical resection status showed significant better overall survival of malignant oncocytic adrenocortical tumors.
UNIV-ANGERS | HCL | CHLS | LAMBRET | FNCLCC | UNIV-LILLE3 | UNIV-LYON1 | UNIV-NANTES | THORAX-UMR | CNRS | UDL | UNIV-PARIS5 | UP-SANTE | MITOVASC | USPC | SORBONNE-UNIVERSITE | UNIV-PARIS-SACLAY | UNIV-PARIS | IGR | UNIV-LILLE | UGA | SU-TI | SU-MEDECINE