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Guillain-BarrÉ syndrome subtype diagnosis: A prospective multicentric European study

Abstract :

INTRODUCTION: There is uncertainty as to whether the Guillain-Barré syndrome (GBS) subtypes, acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN), can be diagnosed electrophysiologically.

METHODS: We prospectively included 58 GBS patients. Electrodiagnostic testing (EDX) was performed at means of 5 and 33 days after disease onset. Two traditional and one recent criteria sets were used to classify studies as demyelinating or axonal. Results were correlated with anti-ganglioside antibodies and reversible conduction failure (RCF).

RESULTS: No classification shifts were observed, but more patients were classified as axonal with recent criteria. RCF and anti-ganglioside antibodies were present in both subtypes, more frequently in the axonal subtype.

DISCUSSION: Serial EDX has no effect on GBS subtype proportions. The absence of exclusive correlation with RCF and anti-ganglioside antibodies may challenge the concept of demyelinating and axonal GBS subtypes based upon electrophysiological criteria. Frequent RCF indicates that nodal/paranodal alterations may represent the main pathophysiology. Muscle Nerve, 2018.

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https://hal.univ-angers.fr/hal-02616885
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 25 mai 2020 - 03:35:53
Dernière modification le : mardi 20 octobre 2020 - 03:11:13

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Peter van den Bergh, Francoise Pieret, John Woodard, Shahram Attarian, Aude-Marie Grapperon, et al.. Guillain-BarrÉ syndrome subtype diagnosis: A prospective multicentric European study. Muscle Nerve, 2018, 58 (1), pp.23-28. ⟨10.1002/mus.26056⟩. ⟨hal-02616885⟩

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