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Effects of mean arterial pressure on arousal in sedated ventilated patients with septic shock: a SEPSISPAM post hoc exploratory study

Youenn Jouan 1 Valerie Seegers 2 Ferhat Meziani 3 Fabien Grelon 4 Bruno Megarbane 5 Nadia Anguel 6 Jean-Paul Mira 7, 8 Pierre-François Dequin 9 Soizic Gergaud 10 Nicolas Weiss 11 François Legay 12, 13 Yves Le Tulzo 14 Marie Conrad 15 Rene Robert 16 Frédéric Gonzalez 17 Christophe Guitton 18 Fabienne Tamion 19 Jean-Marie Tonnelier 20 Pierre Guezennec 21 Thierry van der Linden 22 Antoine Vieillard-Baron 23, 24 Peter Radermacher 25 Pierre Asfar 26, 27
Abstract : Background: It is unknown whether the recommended mean arterial pressure (MAP) target of 65 mmHg during initial resuscitation of septic shock is sufficient to maintain cerebral perfusion. Thus, we tested the hypothesis that a higher MAP target in patients with septic shock may improve level of arousal. Methods: We performed a post hoc exploratory analysis of the SEPSISPAM trial, which assessed the effect of a "high-target" level of MAP (80-85 mmHg) versus the recommended "low-target" MAP (65-70 mm Hg) on mortality in patients with septic shock. Among the 776 patients originally recruited in SEPSISPAM trial, we selected those who were mechanically ventilated and sedated and with available evaluation of arousal level assessed by the Richmond Agitation and Sedation Scale (RASS). Results: We restricted our analysis to the period in which patients were treated with vasoactive drugs. Cumulative sedative drugs were assessed daily. A total of 532 patients were included in this study: 253 (47.6%) in the low-target group and 279 (52.4%) in the high-target group. Daily cumulative sedative drugs were similar in both groups. Compared to the low-target group, minimal and maximal RASS were significantly higher in the high-target group at day 2, 4 and 5. Furthermore, in order to consider the fact that multiple measures were done for each patient and to consider the global effect of time on these measures, we used a mixed linear regression and multivariate models: we confirmed that maximal RASS values were significantly higher in the high-target group. Conclusion: In patients with septic shock who were mechanically ventilated and sedated, resuscitation with MAP target between 80 and 85 mmHg was associated with higher arousal level as compared to a MAP target between 65 and 70 mmHg.
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Youenn Jouan, Valerie Seegers, Ferhat Meziani, Fabien Grelon, Bruno Megarbane, et al.. Effects of mean arterial pressure on arousal in sedated ventilated patients with septic shock: a SEPSISPAM post hoc exploratory study. Annals of Intensive Care, SpringerOpen, 2019, 9 (1), pp.54. ⟨10.1186/s13613-019-0528-5⟩. ⟨hal-02616947⟩

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