High mitochondrial DNA copy number is associated with longer survival in young patients with glioblastoma - Université d'Angers Accéder directement au contenu
Article Dans Une Revue Neuro-Oncology Année : 2019

High mitochondrial DNA copy number is associated with longer survival in young patients with glioblastoma

Résumé

Glioblastoma (GB) is the most common and most aggressive form of diffuse glioma, with a median overall survival of 15 months after standard of care.1 Young GB patients (<40 years old) may carry isocitrate dehydrogenase 1 or 2 (IDH1/2) mutations or, in rare instances, harbor H3F3A or HIST1H3B mutations. Other cases are wild-type for those genes and harbor gain of chromosome (chr) 7, loss of chr 10, and epidermal growth factor receptor (EGFR) amplification (amp). IDH1/2 mutations are associated with longer survival (24 mo), whereas...

Dates et versions

hal-02616951 , version 1 (25-05-2020)

Identifiants

Citer

Laure-Marie Dardaud, Céline Bris, Valérie Desquiret-Dumas, Blandine Boisselier, Emeline Tabouret, et al.. High mitochondrial DNA copy number is associated with longer survival in young patients with glioblastoma. Neuro-Oncology, 2019, 21 (8), pp.1084-1085. ⟨10.1093/neuonc/noz072⟩. ⟨hal-02616951⟩
77 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More