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Article dans une revue

Nonalcoholic Fatty Liver Disease and the Gut Microbiome

Abstract :

Recent progress has allowed a more comprehensive study of the gut microbiota. Gut microbiota helps in health maintenance and gut dysbiosis associates with chronic metabolic diseases. Modulation of short-chain fatty acids and choline bioavailability, lipoprotein lipase induction, alteration of bile acid profile, endogenous alcohol production, or liver inflammation secondary to endotoxemia result from gut dysbiosis. Modulation of the gut microbiota by pre/probiotics gives promising results in animal, but needs to be evaluated in human before use in clinical practice. Gut microbiota adds complexity to the pathophysiology of nonalcoholic fatty liver disease but represents an opportunity to discover new therapeutic targets.

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Article dans une revue
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https://hal.univ-angers.fr/hal-02648803
Contributeur : Okina Université d'Angers <>
Soumis le : vendredi 29 mai 2020 - 10:29:12
Dernière modification le : mercredi 14 octobre 2020 - 04:16:56

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Jérôme Boursier, Anna Mae Diehl. Nonalcoholic Fatty Liver Disease and the Gut Microbiome. Clinics in Liver Disease, 2016, 20 (2), pp.263-75. ⟨10.1016/j.cld.2015.10.012⟩. ⟨hal-02648803⟩

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