Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Sleep apnoea in the asymptomatic elderly: a real issue for the brain?

Abstract :

The link between sleep apnoea and brain structure is unclear; although dysfunction of the hippocampus, middle temporal gyrus and brainstem/cerebellum have been observed previously. However, this link has been little explored in elderly subjects. The aim of this study was to explore the link between sleep apnoea and the brain in an elderly population.226 asymptomatic elderly subjects (age mean±sd 75.3±0.9 years, range 72.3-77.8 years) from the PROOF (Evaluation of Ageing, Autonomic Nervous System Activity and Cardiovascular Events) cohort study were explored using linear voxel-based or cortical thickness with apnoea/hypopnoea index (AHI; mean±sd 15.9±11.5 events·h, range 6-63.6 events·h) as a covariate of main interest. The brain volumes of 20 control subjects, 18 apnoeic (AHI >29 events·h) treated patients and 20 apnoeic untreated patients from this population were compared using voxel-based morphometry, cortical thickness or surface-based analyses.AHI was not associated with any change in local brain volume, cortical thickness or cortex surface. Control subjects, apnoeic treated and untreated patients were not different in terms of local brain volume, cortical thickness or surface.In a specific population of asymptomatic elderly healthy subjects, sleep apnoea does not seem to be associated with a change in local brain volume or in cortical thickness.

Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-02869147
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 15 juin 2020 - 18:34:08
Dernière modification le : mercredi 24 juin 2020 - 16:19:35

Lien texte intégral

Identifiants

Citation

Sébastien Celle, Claire Boutet, Cedric Annweiler, Jean-Claude Barthélémy, Frédéric Roche. Sleep apnoea in the asymptomatic elderly: a real issue for the brain?. European respiratory journal, 2018, 51 (6), pp.1702450. ⟨10.1183/13993003.02450-2017⟩. ⟨hal-02869147⟩

Partager

Métriques

Consultations de la notice

36