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Article dans une revue

Association between hypovitaminosis D and cognitive inhibition impairment during major depression episode

Abstract :

BACKGROUND: Major depressive episode (MDE) has been associated with cognitive functioning alteration and hypovitaminosis D (hypoVD), but the relationship between hypoVD, depression, and cognition is not well understood. We aimed to compare patient with MDE with or without hypoVD in regard of cognitive functioning.

METHODS: 91 patients (38.5 years old, 65.9% female) with MDE were included in a cross-sectional study and were evaluated with a complete cognitive battery. None of the participants were medicated at the time of the inclusion. Serum 25-hydroxyvitamin D was measured using LC-MS/MS method, and hypovitaminosis was defined as 25OHD < 50nmol/L. Covariates were gender, season of dosage, first MDE onset, age, body mass index and depression severity RESULTS: Patients with hypoVD demonstrated a higher stroop intereference index time underscoring that means low cognitive inhibition ability. Mutiple logistic regression confirmed that hypoVD was significantly associated with high stroop interference time index after controlling by gender, season of dosage, first MDE onset, age, body mass index and depression severity.

CONCLUSION: Our results suggest that patient with MDE having hypoVD may be more prone to cognitive impairment.

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Article dans une revue
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https://hal.univ-angers.fr/hal-02869156
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 15 juin 2020 - 18:34:35
Dernière modification le : mercredi 14 octobre 2020 - 04:11:43

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R Belzeaux, Cedric Annweiler, J Bertrand, Olivier Beauchet, S Pichet, et al.. Association between hypovitaminosis D and cognitive inhibition impairment during major depression episode. Journal of Affective Disorders, 2018, 225 (1), pp.302-305. ⟨10.1016/j.jad.2017.08.047⟩. ⟨hal-02869156⟩

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