Egypt has attracted a large number of multinational organizations and become an information technology (IT) hub in the Middle East region. This chapter presents the key issues in Egypt from organizational, technological, and individual perspectives. The top-IT issues in organizations are security and privacy, IT reliability and efficiency, and alignment between IT and business, while globalization, outsourcing, IT cost reduction, and “bring your own device” (BYOD) are the least concerns. The IT infrastructure in Egypt has been developed with recent upgrade of national networks, while networks and telecommunications, virtualization, and enterprise application integration are still highly ranked issues. Social networking/media appears to be the least important issue. The Egyptian IT workers are highly satisfied with their jobs, and they are confident and willing to accomplish their tasks successfully. Egypt has a healthy and growing IT workforce with higher education, strong interests, and both short- and long-term career plans in the IT filed.