C. A. Janeway, How the immune system protects the host from infection, Microbes Infect, vol.3, pp.1167-1171, 2001.

D. D. Chaplin, Overview of the immune response, J. Allergy Clin. Immunol, vol.125, issue.S3, 2010.

F. Castro, A. P. Cardoso, R. M. Goncalves, K. Serre, and M. J. Oliveira, Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion, Front. Immunol, vol.9, 2018.

B. N. Devaiah and D. S. Singer, CIITA and Its Dual Roles in MHC, Gene Transcription. Front. Immunol, 2013.

P. Gavlovsky, P. Tonnerre, C. Guitton, and B. Charreau, Expression of MHC class I-related molecules MICA, HLA-E and EPCR shape endothelial cells with unique functions in innate and adaptive immunity, Hum. Immunol, vol.77, pp.1084-1091, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-02153131

S. González, V. Groh, and T. Spies, Immunobiology of Human NKG2D and Its Ligands, Curr. Top. Microbiol. Immunol, vol.298, pp.121-138, 2006.

N. Nausch and A. Cerwenka, NKG2D ligands in tumor immunity, Oncogene, vol.27, pp.5944-5958, 2008.

Y. Jia, C. Pang, K. Zhao, J. Jiang, T. Zhang et al., Garcinol Suppresses IL-1beta-Induced Chondrocyte Inflammation and Osteoarthritis via Inhibition of the NF-kappaB Signaling Pathway, Inflammation, vol.42, pp.1754-1766, 2019.

S. Coupel, A. Moreau, M. Hamidou, V. Horejsi, J. P. Soulillou et al., Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation, Blood, vol.109, pp.2806-2814, 2007.

N. Jouand, C. Bressollette-bodin, N. Gerard, M. Giral, P. Guerif et al., HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition, PLoS Pathog, vol.14, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-01812003

M. Morvan and L. L. Lanier, NK cells and cancer: You can teach innate cells new tricks, Nat. Rev. Cancer, vol.16, pp.7-19, 2015.

J. A. Bluestone, Mechanisms of tolerance, Immunol. Rev, vol.241, pp.5-19, 2011.

D. Schmiedel and O. Mandelboim, NKG2D Ligands-Critical Targets for Cancer Immune Escape and Therapy, Front. Immunol, vol.9, 2018.

T. Van-hall, P. Andre, A. Horowitz, D. F. Ruan, L. Borst et al., Monalizumab: Inhibiting the novel immune checkpoint NKG2A, J. Immunother. Cancer, vol.7, p.263, 2019.

A. Zingoni, R. Molfetta, C. Fionda, A. Soriani, R. Paolini et al., One for All, All for One, Front. Immunol, vol.9, p.476, 2018.

J. Merza, S. Mallet, M. Litaudon, V. Dumontet, D. Seraphin et al., New cytotoxic guttiferone analogues from Garcinia virgata from New Caledonia, Planta Med, vol.72, pp.87-89, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00020661

C. Rouger, S. Pagie, S. Derbré, A. Le-ray, P. Richomme et al., Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells, PLoS ONE, vol.11, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01412508

M. Iinuma, H. Tosa, T. Tanaka, F. Asai, Y. Kobayashl et al., Antibacterial Activity of Xanthones from Guttiferaeous Plants against Methicillin-resistant Staphylococcus aureus, J. Pharm. Pharmacol, vol.48, pp.861-865, 1996.

R. W. Fuller, J. W. Blunt, J. L. Boswell, J. H. Cardellina, and M. R. Boyd, Guttiferone F, the First Prenylated Benzophenone fromAllanblackia stuhlmannii1, J. Nat. Prod, vol.62, pp.130-132, 1999.

P. Tonnerre, N. Gerard, M. Chatelais, B. Charreau, and . Gene, Polymorphism in Kidney Allografts and Possible Impact of Functionally Relevant Variants, Transplant. Proc, vol.42, pp.4318-4321, 2010.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, vol.25, pp.402-408, 2001.

H. M. Berman, T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne et al., The Protein Data Bank, Acta Crystallogr. Sect. D Biol. Crystallogr, vol.58, pp.899-907, 2002.

M. L. Verdonk, J. C. Cole, M. J. Hartshorn, C. W. Murray, and R. D. Taylor, Improved protein-ligand docking using GOLD, Proteins: Struct. Funct. Bioinform, vol.52, pp.609-623, 2003.

G. Wolber and T. Langer, LigandScout: 3-D Pharmacophores Derived from Protein-Bound Lingands and Their Use as Virtual Screening Filters, J. Chem. Inf. Model, vol.36, pp.160-169, 2005.

A. Chatterjee, T. Yasmin, D. Bagchi, and S. J. Stohs, The bactericidal effects of Lactobacillus acidophilus, garcinol and Protykin compared to clarithromycin, on Helicobacter pylori, Mol. Cell. Biochem, vol.243, pp.29-35, 2003.

K. Al-qahtani, B. Jabeen, R. Sekirnik, N. Riaz, T. D. Claridge et al., The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves, Phytochemistry, vol.117, pp.456-461, 2015.

X. Yang, R. B. Grossman, and G. Xu, Research Progress of Polycyclic Polyprenylated Acylphloroglucinols, Chem. Rev, vol.118, pp.3508-3558, 2018.

. Kewscience, Plants of the World Online. Garcinia L. 2020. Available online, pp.19345-19346, 2020.

. Tropicos, Missouri Botanical Garden, 2020.

A. Bruguiere, S. Derbre, C. Coste, M. Bot, B. Siegler et al., )C-NMR dereplication of Garcinia extracts: Predicted chemical shifts as reliable databases, Fitoterapia, vol.131, issue.13, pp.59-64, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02435038

J. Hubert, J. M. Nuzillard, S. Purson, M. Hamzaoui, N. Borie et al., Identification of natural metabolites in mixture: A pattern recognition strategy based on (13)C NMR, Anal. Chem, vol.86, pp.2955-2962, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01968799

J. Li, R. Gao, D. Zhao, X. Huang, Y. Chen et al., Separation and preparation of xanthochymol and guttiferone E by high performance liquid chromatography and high speed counter-current chromatography combined with silver nitrate coordination reaction, J. Chromatogr. A, pp.143-148, 1511.

D. Roux, H. A. Hadi, S. Thoret, D. Guenard, O. Thoison et al., Structure-activity relationship of polyisoprenyl benzophenones from Garcinia pyrifera on the tubulin/microtubule system, J. Nat. Prod, vol.63, pp.1070-1076, 2000.

S. Coupel, F. Leboeuf, G. Boulday, J. Soulillou, and B. Charreau, RhoA Activation Mediates Phosphatidylinositol 3-Kinase-Dependent Proliferation of Human Vascular Endothelial Cells: An Alloimmune Mechanism of Chronic Allograft Nephropathy, J. Am. Soc. Nephrol, vol.15, pp.2429-2439, 2004.

A. Chauveau, P. Tonnerre, A. Pabois, P. J. Gavlovsky, M. Chatelais et al., Endothelial cell activation and proliferation modulate NKG2D activity by regulating MICA expression and shedding, J. Innate Immun, vol.6, pp.89-104, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-02163395

K. Balasubramanyam, M. Altaf, R. A. Varier, V. Swaminathan, A. Ravindran et al., Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression, J. Biol. Chem, vol.279, pp.33716-33726, 2004.

L. M. Lasko, C. G. Jakob, R. P. Edalji, W. Qiu, D. Montgomery et al., Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours, Nature, vol.550, pp.128-132, 2017.

C. Schindler and C. Plumlee, Inteferons pen the JAK-STAT pathway, Semin. Cell Dev. Boil, vol.19, pp.311-318, 2008.

X. Hu and L. B. Ivashkiv, Cross-regulation of signaling pathways by interferon-gamma: Implications for immune responses and autoimmune diseases, Immunity, vol.31, pp.539-550, 2009.

J. Satoh and H. Tabunoki, A Comprehensive Profile of ChIP-Seq-Based STAT1 Target Genes Suggests the Complexity of STAT1-Mediated Gene Regulatory Mechanisms, Gene Regul. Syst. Biol, vol.7, pp.41-56, 2013.

J. J. O'shea and P. J. Murray, Cytokine signaling modules in inflammatory responses, Immunity, vol.28, pp.477-487, 2008.

P. R. Thompson, D. Wang, L. Wang, M. Fulco, N. Pediconi et al., Regulation of the p300 HAT domain via a novel activation loop, Nat. Struct. Mol. Biol, vol.11, pp.308-315, 2004.

O. H. Kramer and T. Heinzel, Phosphorylation-acetylation switch in the regulation of STAT1 signaling, Mol. Cell. Endocrinol, vol.315, pp.40-48, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00547660

S. Zhuang, Regulation of STAT signaling by acetylation, Cell. Signal, vol.25, 1924.

W. Min, J. S. Pober, and D. R. Johnson, Kinetically coordinated induction of TAP1 and HLA class I by IFN-gamma: The rapid induction of TAP1 by IFN-gamma is mediated by Stat1 alpha, J. Immunol, vol.156, pp.3174-3183, 1996.

J. A. Herberg, J. Sgouros, T. Jones, J. Copeman, S. J. Humphray et al., Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC, Eur. J. Immunol, vol.28, pp.459-467, 1998.

P. J. Van-den-elsen, T. M. Holling, H. F. Kuipers, and N. Van-der-stoep, Transcriptional regulation of antigen presentation, Curr. Opin. Immunol, vol.16, pp.67-75, 2004.

M. S. Leibowitz, R. M. Srivastava, P. A. Andrade-filho, A. M. Egloff, L. Wang et al., SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.19, pp.798-808, 2013.

C. Spilianakis, A. Kretsovali, T. Agalioti, T. Makatounakis, D. Thanos et al., CIITA regulates transcription onset viaSer5-phosphorylation of RNA Pol II, EMBO J, vol.22, pp.5125-5136, 2003.

T. Oike, H. Ogiwara, K. Torikai, T. Nakano, J. Yokota et al., Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining, Int. J. Radiat. Oncol. Biol. Phys, vol.84, pp.815-821, 2012.

B. Wang, L. Lin, Q. Ai, T. Zeng, P. Ge et al., HAT inhibitor, garcinol, exacerbates lipopolysaccharideinduced inflammation in vitro and in vivo, Mol. Med. Rep, vol.13, pp.5290-5296, 2016.

J. Wang, M. Wu, D. Zheng, H. Zhang, Y. Lv et al., Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-beta1 signaling pathways, Acta Pharmacol. Sin, vol.41, pp.82-92, 2020.

H. M. Chan and N. La-thangue, B. p300/CBP proteins: HATs for transcriptional bridges and scaffolds, J. Cell Sci, vol.114, pp.2363-2373, 2001.
URL : https://hal.archives-ouvertes.fr/in2p3-00590761

A. A. Celik, T. Kraemer, T. Huyton, and R. Blasczyk, Bade-Doding, C. The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch, Immunogenetics, vol.68, pp.29-41, 2016.