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Article dans une revue

Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers

Abstract :

Advanced glycation end-products, namely AGEs, are involved in the pathogenesis of numerous diseases. If AGEs inhibitors are well-known, only few products are described as compounds able to destroy those deleterious products. In this work, we describe naphthoic acid derivatives, particularly 1-(naphthalen-1-yl)propane-1,2-dione 9, allowing the simple and rapid detection of AGEs breakers using a 96-well microplate fluorescence assay. Since the inaugurate publication about AGEs breakers whose activity was demonstrated using HPLC analysis, this work proposes the first assay suitable for automated and high throughput screening of AGEs breakers.

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https://hal.univ-angers.fr/hal-03027816
Contributeur : Okina Université d'Angers <>
Soumis le : vendredi 27 novembre 2020 - 12:28:11
Dernière modification le : jeudi 3 décembre 2020 - 03:28:54
Archivage à long terme le : : dimanche 28 février 2021 - 19:19:08

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Luc Séro, François Calard, Lionel Sanguinet, Eric Levillain, Pascal Richomme, et al.. Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2012, 22 (21), pp.6716 - 6720. ⟨10.1016/j.bmcl.2012.08.092⟩. ⟨hal-03027816⟩

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