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Evaluation of a new matrix-free laser desorption/ionization method through statistic studies: comparison of the DIAMS (desorption/ionization on self-assembled monolayer surface) method with the MALDI and TGFA-LDI techniques

Abstract :

This work demonstrates that the desorption/ionization on self-assembled monolayer surface (DIAMS) mass spectrometry, a recent matrix-free laser desorption/ionization (LDI) method based on an organic target plate, is as statistically repeatable and reproducible as matrix assisted laser desorption ionization (MALDI) and thin gold film-assisted laser desorption/ionization (TGFA-LDI) mass spectrometries. On lipophilic DIAMS of target plates with a mixture of glycerides, repeatability/reproducibility has been estimated at 15 and 30% and the relative detection limit has been evaluated at 0.3 and 3 pmol, with and without NaI respectively. Salicylic acid and its d6-isomer analysis confirm the applicability of the DIAMS method in the detection of compounds of low molecular weight.

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https://hal.univ-angers.fr/hal-03027828
Contributeur : Okina Université d'Angers <>
Soumis le : vendredi 27 novembre 2020 - 12:28:34
Dernière modification le : lundi 10 mai 2021 - 16:52:01
Archivage à long terme le : : dimanche 28 février 2021 - 19:19:31

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Matthieu Bounichou, Lionel Sanguinet, Kamal Elouarzaki, Olivier Alévêque, Marylène Dias, et al.. Evaluation of a new matrix-free laser desorption/ionization method through statistic studies: comparison of the DIAMS (desorption/ionization on self-assembled monolayer surface) method with the MALDI and TGFA-LDI techniques. Journal of Mass Spectrometry, 2008, 43 (12), pp.1618 - 1626. ⟨10.1002/jms.1414⟩. ⟨hal-03027828⟩

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