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SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics

Abstract : Glioma is a type of cancer with a very poor prognosis with a survival of around 15 months in the case of glioblastoma multiforme (GBM). In order to advance in personalized medicine, we developed polymeric nanoparticles (PNP) loaded with both SPION (Superparamagnetic Iron Oxide Nanoparticles) and doxorubicin (DOX). The former being used for its potential to accumulate the PNP in the tumor under a strong magnetic field and the later for its therapeutic potential. The emulsion solvent and evaporation method was selected to develop monodisperse PNP with high loading efficiency in both SPION and DOX. Once injected in mice, a significant accumulation of the PNP was observed within the tumoral tissue under static magnetic field as observed by MRI leading to a reduction of tumor growth rate.
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https://hal.univ-angers.fr/hal-03129744
Contributeur : Laurent Lemaire <>
Soumis le : mercredi 3 février 2021 - 09:20:44
Dernière modification le : mardi 3 août 2021 - 18:28:03
Archivage à long terme le : : mardi 4 mai 2021 - 18:20:10

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Edurne Luque-Michel, Laurent Lemaire, Maria Blanco-Prieto. SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics. Drug Delivery and Translational Research, Springer, 2021, ⟨10.1007/s13346-020-00880-8⟩. ⟨hal-03129744⟩

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