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Feasibility of, and critical paths for mycophenolate mofetil Bayesian dose adjustment: Pharmacological re-appraisal of a concentration-controlled versus fixed-dose trial in renal transplant recipients

Abstract :

The aim of this study was to analyze retrospectively and critically the different steps of the individual dose adjustment procedure employed in the concentration-controlled (CC) versus fixed-dose trial Apomygre, which showed that mycophenolate mofetil (MMF) dose adjustment using a limited sampling strategy significantly reduced the risk of treatment failures and acute rejection in renal transplants at one year posttransplantation.The number of AUCs performed during the study and circumstances of collection, time of blood sampling, Bayesian mycophenolic acid (MPA) area-under-the-curve (AUC) estimation procedures and physicians’ compliance with MMF dose recommendations were retrospectively analyzed. 92% of AUCs scheduled over the study were actually performed. Sampling times were very well respected. Bayesian estimation of MPA exposure was done by the pharmacologists locally in accordance with the protocol instructions and the AUC estimates obtained were virtually all confirmed a posteriori. On the other hand, a second AUC estimated by multiple linear regression could only be provided for 84% of the profiles and showed a large overestimation with respect to Bayesian estimates for AUC values between 10 and 55 mg h/L. In the CC arm, a very good physicians’ compliance was observed (85%) and application of the dose recommendations led to higher values of AUCs (42.1 ± 14.6 mg h/L versus 36.7 ± 16.3 mg h/L, p = 0.0035) and to more AUCs in the target range (69% versus 56%, p = 0.0343) than when dose recommendations were not applied. By analyzing in detail the feasibility criteria of MMF Bayesian dose adjustment, this study highlighted the requirements for successful extrapolation of the Apomygre trial results to routine practice: (i) respect of the PK sampling time-windows; (ii) use of relevant tools for accurate drug exposure estimation and dose adjustment calculation; and (iii) good compliance of the physicians with regard to the recommended doses.

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https://hal.univ-angers.fr/hal-03134625
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 8 février 2021 - 14:26:37
Dernière modification le : lundi 17 mai 2021 - 14:52:11

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Aurelie Prémaud, Annick Rousseau, Yannick Le Meur, Nicolas Venisse, Cecile Loichot-Roselmac, et al.. Feasibility of, and critical paths for mycophenolate mofetil Bayesian dose adjustment: Pharmacological re-appraisal of a concentration-controlled versus fixed-dose trial in renal transplant recipients. Pharmacological Research, Elsevier, 2010, 61 (2), pp.167 - 174. ⟨10.1016/j.phrs.2009.09.006⟩. ⟨hal-03134625⟩

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