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Article dans une revue

New starch-based radiotracer for lung perfusion scintigraphy

Abstract :

PURPOSE:

In order to avoid the microbiological risks linked to human serum albumin macroaggregates (MAA) used for lung perfusion scintigraphy, we developed a new starch-based Tc-99m potential radiopharmaceutical.

METHODS:

Microparticles were prepared from oxidised starch coupled to natural polyamine for Tc-99m complexation. Suspensions were formulated as ready-to-use kits for easy one-step labelling procedures.

RESULTS:

Particle-size analysis, electron microscopy, and confocal microscopy were performed for microparticle characterisation, and gave a typical size distribution ranging from 7 to 63 microm, with a homogenous population of spherical or oval-shaped microparticles. Radiochemical purity exceeded 95%, and was stable for at least 8 h. When challenged with histidine and human plasma, labelling was also stable. Dynamic scintigraphic acquisitions and biodistribution studies conducted on healthy Wistar rats showed a tracer accumulation with more than 80% of the ID in the lungs after 15 min.

CONCLUSIONS:

With clinically significant characteristics such as a lung half-life of 3 h, a lung-to-vascular ratio of 900, and a lung-to-liver ratio of 90, starch-based microparticles exhibit all the qualities for an effective new lung perfusion agent.

Type de document :
Article dans une revue
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https://hal.univ-angers.fr/hal-03134648
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Soumis le : lundi 8 février 2021 - 14:27:29
Dernière modification le : mardi 9 février 2021 - 03:25:19

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Franck Lacœuille, François Hindré, Benoit Denizot, Francis Bouchet, Pierre Legras, et al.. New starch-based radiotracer for lung perfusion scintigraphy. European Journal of Nuclear Medicine and Molecular Imaging, 2010, 37 (1), pp.146-155. ⟨10.1007/s00259-009-1226-6⟩. ⟨hal-03134648⟩

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