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Communication dans un congrès

Is M. ulcerans able to colonize neuronal cells?

Abstract :

Buruli ulcer, or Mycobacterium ulcerans infection, is an emerging disease, principally diagnosed in humid tropical countries and inducing large skin ulcers. These lesions are painless, a distinct feature that suggests that the mycolactone toxin and/or M. ulcerans impedes the signal transmission by the nervous system. In this context, the aim of this work was to study the interaction between M. ulcerans and neuronal cells by using in vitro and in vivo models. We showed that a virulent strain of M. ulcerans is able to enter into neurons cultivated from neonatal rat hippocampus. On the contrary, this phenomenon was less observed with a mycolactone-deficient strain. To support these data, we analysed nerve fibres from mouse-infected tissues and few bacilli were found in close contact with nerve fibres. The invasion process established by M. ulcerans to colonize the nervous system remains uncharacterised, but we hypothesise that this ability could be involved in the painless of the M. ulcerans infection.

Type de document :
Communication dans un congrès
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Contributeur : Okina Univ Angers Connectez-vous pour contacter le contributeur
Soumis le : mercredi 10 février 2021 - 14:28:14
Dernière modification le : mercredi 19 janvier 2022 - 16:34:02


  • HAL Id : hal-03137476, version 1
  • OKINA : ua11322



Estelle Marion, Caroline Deshayes, C. Dantec, Emmanuel Garcion, Timothy Stinear, et al.. Is M. ulcerans able to colonize neuronal cells?. 14th annual meeting on Buruli ulcer, 2011, Genève, Suisse. pp.103. ⟨hal-03137476⟩



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