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Article dans une revue

The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy

M. Roger 1 Anne Clavreul 2 Marie-Claire Venier-Julienne 2 Catherine Passirani-Malleret 2 Claudia Montero-Menei 2 Philippe Menei 2
1 GMT - Groupe Modélisation et Théorie
IRAMIS - Institut Rayonnement Matière de Saclay, SPEC - UMR3680 - Service de physique de l'état condensé
Abstract :

The prognosis of patients with malignant glioma remains extremely poor, despite surgery and improvements in radio- and chemo-therapies. Nanotechnologies hold great promise in glioma therapy as they protect the therapeutic agent and allow its sustained release. However, new paradigms permitting tumor-specific targeting and extensive intratumoral distribution must be developed to efficiently deliver nanoparticles. Modifications and functionalizations of nanoparticles have been developed to specifically track tumor cells. However, these nanoparticles have yielded few clinical results due to intra-patient heterogeneity and inter-patient variability. Stem cells with a specific tropism for brain tumors could be used as delivery vehicles for nanoparticles. Indeed, these cells have a natural tendency to migrate and distribute within the tumor mass and they can also incorporate nanoparticles. Stem cell therapy combined with nanotechnology could be a promising tool to efficiently deliver drugs to brain tumors.

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Article dans une revue
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Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 10 mars 2021 - 16:31:11
Dernière modification le : jeudi 11 mars 2021 - 03:43:25


  • HAL Id : hal-03165474, version 1
  • OKINA : ua3673



M. Roger, Anne Clavreul, Marie-Claire Venier-Julienne, Catherine Passirani-Malleret, Claudia Montero-Menei, et al.. The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy. Biomaterials, Elsevier, 2011, 32 (8), pp.1560-1573. ⟨hal-03165474⟩



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