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Article dans une revue

Convection-enhanced delivery of nanocarriers for the treatment of brain tumors

Abstract :

Primary brain tumors have a significant infiltrative capacity as their reappearance after resection usually occurs within 2cm of the tumor margin. Local delivery method such as Convection-Enhanced Delivery (CED) has been introduced to avoid this recurrence by delivering active molecules via positive-pressure methods. For an efficient infusion, the distribution volume of the drug has to be optimized while avoiding backflow, since this is responsible for side effects and a reduction of therapeutic efficacy. The encapsulation of the drug infused in nanosized structures can be considered, which would lead to a reduction of both toxicity of the treatment and infusion time during CED. In the present review, we will firstly discuss the technical approach of CED with regard to catheter design and brain characteristics; secondly, we will describe the 'ideal' nanocarrier in terms of size, surface properties, and interaction with the extracellular matrix for optimal diffusion in the brain parenchyma. We also discuss preclinical and clinical applications of this new method.

Type de document :
Article dans une revue
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Soumis le : mercredi 17 mars 2021 - 11:12:49
Dernière modification le : mercredi 20 octobre 2021 - 03:19:23


  • HAL Id : hal-03171802, version 1
  • OKINA : ua3760



Emilie Allard-Vannier, Catherine Passirani-Malleret, Jean-Pierre Benoît. Convection-enhanced delivery of nanocarriers for the treatment of brain tumors. Biomaterials, Elsevier, 2009, 30 (12), pp.2302-18. ⟨hal-03171802⟩



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