Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Autologous tumor cell vaccination plus infusion of GM-CSF by a programmable pump in the treatment of recurrent malignant gliomas

Abstract : We report on the safety and feasibility of autologous tumor cell vaccination combined with infusion of granulocyte-macrophage colony-stimulating factor by a programmable pump in the treatment of recurrent malignant gliomas. The programmable pump is a promising tool used to infuse cytokines subcutaneously for vaccination. Our trial enrolled nine patients who had undergone surgery, radiation and had been successfully weaned off steroids. Unfortunately, only five patients completed the protocol and were monitored for side effects, local reactions, delayed-type hypersensitivity (DTH) responses and survival. The treatment was well tolerated. Two patients developed DTH reactions after vaccination and three patients had an unusually long survival without any other treatment. Despite the few patients treated, the results of this trial are encouraging. This study also highlights the specific difficulties encountered in vaccination programs for the treatment of glioma.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-03171838
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 17 mars 2021 - 11:24:27
Dernière modification le : samedi 20 mars 2021 - 03:26:42

Identifiants

Collections

Citation

Anne Clavreul, N. Piard, Jean-Yves Tanguy, Erik Gamelin, Marie-Christine Rousselet, et al.. Autologous tumor cell vaccination plus infusion of GM-CSF by a programmable pump in the treatment of recurrent malignant gliomas. Journal of Clinical Neuroscience, Elsevier, 2010, 17 (7), pp.842-848. ⟨10.1016/j.jocn.2009.11.017⟩. ⟨hal-03171838⟩

Partager

Métriques

Consultations de la notice

21