Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Stealth macromolecular platforms for the design of MRI blood pool contrast agents

Abstract : Stealth macromolecular platforms bearing alkyne groups and poly(ethylene oxide) brushes were synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. The anchoring of Gd3+-chelates bearing an azide group was then carried out by the Huisgen 1,3-dipolar cycloaddition (“click”) reaction in mild conditions, leading to macrocontrast agents for MRI applications. The gadolinium complex is hidden in the PEO shell that renders the macrocontrast agents free of any cytotoxicity and stealth to proteins of the immune system. Relaxometry measurements have evidenced an improved relaxivity of the macrocontrast agent compared to ungrafted gadolinium chelate. Moreover, this relaxivity is further enhanced when the spacer length between the Gd3+-chelate and the polymer backbone is shorter, as the result of its decreased tumbling rate. These novel products are therefore promising candidates for MRI applications.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-03171877
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 17 mars 2021 - 11:25:28
Dernière modification le : jeudi 18 mars 2021 - 03:20:11
Archivage à long terme le : : lundi 21 juin 2021 - 08:56:15

Fichier

c1py00198a.pdf
Accord explicite pour ce dépôt

Identifiants

Collections

Citation

M. Grogna, R. Cloots, A. Luxen, Christine Jérôme, Catherine Passirani-Malleret, et al.. Stealth macromolecular platforms for the design of MRI blood pool contrast agents. Polymer Chemistry, Royal Society of Chemistry - RSC, 2011, 2 (10), pp.2316-27. ⟨10.1039/c1py00198a⟩. ⟨hal-03171877⟩

Partager

Métriques

Consultations de la notice

12

Téléchargements de fichiers

17