Stealth macromolecular platforms for the design of MRI blood pool contrast agents - Université d'Angers Accéder directement au contenu
Article Dans Une Revue Polymer Chemistry Année : 2011

Stealth macromolecular platforms for the design of MRI blood pool contrast agents

Résumé

Stealth macromolecular platforms bearing alkyne groups and poly(ethylene oxide) brushes were synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. The anchoring of Gd3+-chelates bearing an azide group was then carried out by the Huisgen 1,3-dipolar cycloaddition (“click”) reaction in mild conditions, leading to macrocontrast agents for MRI applications. The gadolinium complex is hidden in the PEO shell that renders the macrocontrast agents free of any cytotoxicity and stealth to proteins of the immune system. Relaxometry measurements have evidenced an improved relaxivity of the macrocontrast agent compared to ungrafted gadolinium chelate. Moreover, this relaxivity is further enhanced when the spacer length between the Gd3+-chelate and the polymer backbone is shorter, as the result of its decreased tumbling rate. These novel products are therefore promising candidates for MRI applications.
Fichier principal
Vignette du fichier
c1py00198a.pdf (609.4 Ko) Télécharger le fichier
Origine : Accord explicite pour ce dépôt

Dates et versions

hal-03171877 , version 1 (17-03-2021)

Identifiants

Citer

M. Grogna, R. Cloots, A. Luxen, Christine Jérôme, Catherine Passirani-Malleret, et al.. Stealth macromolecular platforms for the design of MRI blood pool contrast agents. Polymer Chemistry, 2011, 2 (10), pp.2316-27. ⟨10.1039/c1py00198a⟩. ⟨hal-03171877⟩

Collections

CNRS UNIV-ANGERS
10 Consultations
45 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More