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Article dans une revue

External irradiation models for intracranial 9L glioma studies

Abstract : Purpose: Radiotherapy has been shown to be an effective for the treatment human glioma and consists of 30 fractions of 2 Gy each for 6-7 weeks in the tumor volume with margins. However. in preclinical studies, many different radiation schedules are used. The main purpose of this work was to review the relevant literature and to propose an external whole-brain irradiation (WBI) protocol for a rat 9L glioma model. Materials and methods: 9L cells were implanted in the striatum of twenty 344-Fisher rats to induce a brain tumor. On day 8, animals were randomized in two groups: an untreated group and an irradiated group with three fractions of 6 Gy at day 8, 11 and 14. Survival and toxicity were assessed. Results: Irradiated rats had significantly a longer survival (p = 0.01). No deaths occurred due to the treatment. Toxicities of reduced weight and alopecia were increased during the radiation period but no serious morbidity or mortality was observed. Moreover, abnormalities disappeared the week following the end of the therapeutic schedule. Conclusions: Delivering 18 Gy in 3 fractions of 6 Gy every 3 days, with mild anaesthesia, is safe, easy to reproduce and allows for standardisation in preclinical studies of different treatment regimens glioma rat model.
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Soumis le : mercredi 17 mars 2021 - 11:25:29
Dernière modification le : jeudi 21 avril 2022 - 03:29:23

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S. Vinchon-Petit, D. Jarnet, Eric Jadaud, L. Feuvret, Emmanuel Garcion, et al.. External irradiation models for intracranial 9L glioma studies. Journal of experimental & clinical cancer research, BioMed Central, 2010, 29, pp.142. ⟨10.1186/1756-9966-29-142⟩. ⟨hal-03171878⟩



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