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Article dans une revue

Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms

Abstract :

Over the last decade, Lipid NanoCapsules (LNCs) have been intensively used as effective drug delivery systems; they are classically prepared using a phase-inversion method. Following formulation of the LNCs, the molecular insertion of commercially-available disteraoylphosphatidylethanolamine-peg amphiphiles is performed into the LNC shell, using a post-insertion method, more classically applied with liposomes. The subsequent LNC interfacial modifications are investigated by using size and electrokinetic measurements. More particularly, the length and the nature of the hydrophilic part of the post-inserted surfactant are modified. The results are discussed in order to improve our understanding of post-insertion mechanisms.

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Soumis le : mercredi 17 mars 2021 - 11:31:36
Dernière modification le : mardi 13 septembre 2022 - 17:07:06




Thomas Perrier, Patrick Saulnier, Florian Fouchet, Nolwenn Lautram, Jean-Pierre Benoît. Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms. International Journal of Pharmaceutics, Elsevier, 2010, 396 (1-2), pp.204-9. ⟨10.1016/j.ijpharm.2010.06.019⟩. ⟨hal-03171893⟩



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