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Day time and night time effects of 24R,25-dihydroxycholecalciferol on renal alkaline phophatase and gamma-glutamyltransferase activities in intact rats.

Abstract : The effects of 24R, 25-dihydroxycholecalciferol [24, 25(OH)2 CC] on alkaline phosphatase (APA), gamma-glutamyltransferase (γ-GT) and acid phosphatase (AP) activities were investigated on renal cortex slices of intact rats killed at 18h00 or at 06h00. At 06h00, three, six and nine hours after a single intraperitoneal injection of 24, 25(OH)2 CC, APA activity was increased by 30%, 51% and 29%, respectivley and γ-GT activity, by 25%, 39% and 38%, as compared to their controls. AP on the other hand was not modified at all. These enzymatic stimulations were statistically higher than those measured at 18h00, respectively APA: 11%, 25%, 28% and γ-GT: 2%, 20%, 22%. They can be explained by variations in new protein synthesis in relation with rat activity periods. Physiological significance of these renal effects remains to be elaborated.
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https://hal.univ-angers.fr/hal-03175696
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Soumis le : lundi 22 mars 2021 - 19:31:02
Dernière modification le : mardi 23 mars 2021 - 09:29:02
Archivage à long terme le : : mercredi 23 juin 2021 - 18:09:46

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1994-Archives Int Physiol Bioc...
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X. Do Thanh, P. Boisnard, Mustayeen A. Khan, A. Girault.. Day time and night time effects of 24R,25-dihydroxycholecalciferol on renal alkaline phophatase and gamma-glutamyltransferase activities in intact rats.. ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE Biochimie ET DE BIOPHYSIQUE, 1994, 102 (3), pp.221-224. ⟨10.3109/13813459409007542⟩. ⟨hal-03175696⟩

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