Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Aqueous core nanocapsules: a new solution for encapsulating doxorubicin hydrochloride

Abstract :

In this study, we propose a new solution for the nanoencapsulation of hydrophilic anticancer drug, doxorubicin hydrochloride (DOX). The drug molecules are solubilized in the core of aqueous nanoreservoirs, so-called aqueous core nanocapsules (ACN) recently developed by our team, and dispersed in aqueous bulk media. Since it is well acknowledged that the nanoencapsulation of DOX has many advantages, like reducing the sides effects (e.g. cardiac toxicity), we propose through the present study a novel formulation solution for this purpose. After focusing on the formulation process for optimizing the drug encapsulation yield, the DOX-release profiles were followed up and analyzed. Different physicochemical and in vitro characterization were performed, and complement activation experiments. ACN were shown efficient to encapsulate DOX reaching yields as high as 80%, followed by a sustained release governed by a diffusion-controlled mechanism. The loaded nanocarriers showed low levels of complement activation, compatible with stealth properties. To summarize, this study brings out a new tool for the nanoencapsulation of hydrophilic anticancers and could open new doors for the administration of this particular class of drugs.


Read More: http://informahealthcare.com/doi/abs/10.3109/03639045.2012.730526

Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-03178895
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 24 mars 2021 - 09:49:49
Dernière modification le : jeudi 25 mars 2021 - 15:33:09
Archivage à long terme le : : vendredi 25 juin 2021 - 18:20:46

Fichier

vrignaud_2013_aqueous_core_nan...
Accord explicite pour ce dépôt

Identifiants

Collections

Citation

Sandy Vrignaud, Nicolas Anton, Catherine Passirani-Malleret, Jean-Pierre Benoit, Patrick Saulnier. Aqueous core nanocapsules: a new solution for encapsulating doxorubicin hydrochloride. Drug Development and Industrial Pharmacy, Taylor & Francis, 2013, 39 (11), pp.1706-11. ⟨10.3109/03639045.2012.730526⟩. ⟨hal-03178895⟩

Partager

Métriques

Consultations de la notice

27

Téléchargements de fichiers

49