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In vivo evaluation of poly-l-asparagine nanocapsules as carriers for anti-cancer drug delivery

Abstract :

Here, we report the in vivo proof of-concept of a novel nanocarrier, poly-l-asparagine (PASN) nanocapsules, as an anticancer targeted drug delivery system. The nanocapsules were loaded with the fluorescent marker DiD (1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine perchlorate) and also with the model drug docetaxel to evaluate the biodistribution and efficacy profiles in healthy and glioma-bearing mice, respectively. Regardless of their cargo, the nanocapsules presented a size close to 180 nm, a surface charge around -40 mV and an encapsulation efficiency of 75-90%. The biodistribution study in healthy mice showed that PASN nanocapsules led to a two- and three-fold increment in the mean residence time (MRT) and area under the curve (AUC) values, respectively, compared to those of a non-polymeric nanoemulsion. Finally, the efficacy/toxicity study indicated that the encapsulated drug was as efficacious as the commercial formulation (Taxotere(®)), with the additional advantage of being considerably less toxic. Overall, these results suggest the potential of PASN nanocapsules as drug nanocarriers in anticancer therapy.

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https://hal.univ-angers.fr/hal-03178899
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 24 mars 2021 - 09:49:55
Dernière modification le : jeudi 15 avril 2021 - 17:20:49

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Gustavo Rivera-Rodriguez, Giovanna Lollo, Tristan Montier, Jean-Pierre Benoit, Catherine Passirani-Malleret, et al.. In vivo evaluation of poly-l-asparagine nanocapsules as carriers for anti-cancer drug delivery. International Journal of Pharmaceutics, Elsevier, 2013, 458 (1), pp.83-9. ⟨10.1016/j.ijpharm.2013.09.038⟩. ⟨hal-03178899⟩

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