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Article dans une revue

Exploring ripening of nanocapsules and emulsions in parenteral nutritional mixtures by experimental design

Abstract :

Lipid nanocapsules based on vegetal oils (vo-LNC) can be prepared and used to allow both the easy incorporation of oils in the aqueous phase and the stability of mixtures for parenteral nutrition. In this context of use, vo-LNC was shown an interesting process of ripening. To explore this ripening process, experimental design was used. The same mixture design was performed for both the incorporation of lipids by vo-LNC as by emulsion. The responses chosen for the experimental design was the average size and zeta potential of both. As expected, vo-LNC and emulsion were affected at different level by the ripening process. This indicates clearly that vo-LNC would permit the early incorporation of lipids in parenteral nutrition admixtures without any risk of instability and can be safely administered for parenteral use.

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https://hal.univ-angers.fr/hal-03179498
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 24 mars 2021 - 12:22:41
Dernière modification le : jeudi 1 avril 2021 - 18:30:23

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Y. Rahali, Patrick Saulnier, Jean-Pierre Benoit, Y. Bensouda. Exploring ripening of nanocapsules and emulsions in parenteral nutritional mixtures by experimental design. Journal of Drug Delivery Science and Technology, Elsevier, 2013, 23 (3), pp.255-260. ⟨10.1016/S1773-2247(13)50038-4⟩. ⟨hal-03179498⟩

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