Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Cytotoxicity of metallic complexes of furan oximes in murine and human tissue cultured cell lines.

Abstract : The copper complexes of furan oxime derivatives were found to be potent cytotoxic agents in both murine and human tissue cultured cell lines which were suspended as well as solid tumors. Mode of action studies in murine L1210 lymphoid leukemia cells showed that the compounds suppressed DNA, RNA and protein synthesis after 60 min at 100 μM. Inhibition of purine and pyrimidine de novo syntheses, as well as inhibition of ribonucleoside reductase and nucleoside kinase activities with DNA strand scission occurred. All of these effects of the drug probably added to its ability to cause cell death but most important was the inhibition of DNA topoisomerase II activity with IC50 values lower than those afforded by VP‐16, the standard, which should cause apoptosis. © 1997 John Wiley & Sons, Ltd.
Type de document :
Article dans une revue
Domaine :
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-03190047
Contributeur : Mustayeen Khan <>
Soumis le : jeudi 8 avril 2021 - 12:33:37
Dernière modification le : jeudi 8 avril 2021 - 15:08:06

Fichier

1997-Appl Organomet Chem-Hall....
Accord explicite pour ce dépôt

Identifiants

Collections

Citation

Iris H. Hall, Christian C. Lee, Ghassan Ibrahim, Mustayeen A. Khan, Gilles M. Bouet.. Cytotoxicity of metallic complexes of furan oximes in murine and human tissue cultured cell lines.. Applied Organometallic Chemistry, Wiley-Blackwell, 1997, 11 (7), pp.565-575. ⟨10.1002/(SICI)1099-0739(199707)11:7<565::AID-AOC608>3.0.CO;2-I⟩. ⟨hal-03190047⟩

Partager

Métriques

Consultations de la notice

8

Téléchargements de fichiers

18