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Spring time and autumn time toxic effects of copper(II), 3-(2-Furyl) Prop-2-enal semicarbazone and [CuCl2(FASC)2] complex in mice.

Abstract : In vitro, 3-(2-furyl) prop-2-enal semicarbazone-copper (II) complex [CuCl2(FASC)2] presents antimitotic effects. In this work we studied the in vivo seasonal toxic effects in male Swiss mice of CuCl2, and FASC and the [CuCl2(FASC)2] complex. In spring, one injection of CuCl28.10-2 mmol killed 16% of animals after 24 h. Cupric chloride lethal dose was up to 64.10-2 mmol with 100% mice dead after 24 h. FASC was well tolerated from 0.65 to 1.3 mmol. The complex was 100% lethal with 48.10−2 mmol. In autumn, mice were more sensitive to CuCl2 and to the complex with lethal doses up to 32.10-2 mmol and 8.10-2 mmol, respectively. On the other hand, FASC was well tolerated. It is concluded that the in vivo toxic effects of CuCl2 and [CuCl2(FASC)2] complex are quite different in spring and autumn.
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https://hal.univ-angers.fr/hal-03195592
Contributeur : Mustayeen Khan <>
Soumis le : jeudi 15 avril 2021 - 14:26:21
Dernière modification le : vendredi 16 avril 2021 - 10:45:10
Archivage à long terme le : : vendredi 16 juillet 2021 - 18:04:52

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B. Jamali, G. Ibrahim, G. Bouet, Mustayeen A. Khan, P. Allain, et al.. Spring time and autumn time toxic effects of copper(II), 3-(2-Furyl) Prop-2-enal semicarbazone and [CuCl2(FASC)2] complex in mice.. Biological Rhythm Research, Taylor & Francis, 1998, 29 (3), pp.229-236. ⟨10.1076/brhm.29.3.229.1438⟩. ⟨hal-03195592⟩

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