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Stability, Toxicity and Cytotoxicity of a Cupric Complex Towards Cultured CaCo-2 Cells.

Abstract : The human colon adenocarcinoma-derived cell line CaCo-2 was used as a model system to study the effects of copper (II), tetradentate N-alkyl ligand (H2L) and their complex. The stimulatory effect of the complex was obtained with lower concentrations from 10(-7) to 10(-17) mol.L-1, while inhibiting effects occur from 10(-4) to 10(-6) mol.L-1. According to this study, copper (II) and free ligand were toxic for cultured cells. Our data suggested that the complex, according to our toxicity assays in mice, could be used as an antimitotic agent.
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https://hal.univ-angers.fr/hal-03208739
Contributeur : Mustayeen Khan <>
Soumis le : vendredi 30 avril 2021 - 12:54:27
Dernière modification le : lundi 3 mai 2021 - 14:06:39

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  • HAL Id : hal-03208739, version 1

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X. Do Thanh, Safia Djebbar-Sid, Ouassini Benali-Baitich, Gwenaëlle Pehu, Mustayeen A. Khan, et al.. Stability, Toxicity and Cytotoxicity of a Cupric Complex Towards Cultured CaCo-2 Cells.. Anticancer Research, International Institute of Anticancer Research, 2000, 20 (6B), pp.4639-4642. ⟨hal-03208739⟩

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